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SQUIDs from Physics to Brain Research

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Abstract

Superconducting Quantum Interference Devices (SQUlDs) can be utilized to construct extremely sensitive magnetometers for brain research. Magnetoencephalographic (MEG) arrays of hundreds of individual SQUID sensors are now in use in over 80 laboratories worldwide. This paper describes the development of four multi-channel MEG arrays of increasing complexity and power at the Low Temperature Laboratory (LTL) under the guidance of Academician Olli Lounasmaa. TWe impact of the availability of these multi-channel MEG arrays on our capacity to characterize the dynamics of both normal and abnormal brain activity is discussed through examples drawn from research conducted at LTL.

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REFERENCES

  1. J.M.J. Murre and D.P.F. Sturdy, Biological Cybernetics 73, 529(1995).

    Google Scholar 

  2. R.C. Jacklevic, J. Lambe, A.H. Silver and J.E. Mercereau, Phys. Rev. Lett. 12, 159(1964).

    Google Scholar 

  3. J.E. Zimmerman, P. Thiene and J.T. Harding, J. Appl. Phys. 41, 1572(1970).

    Google Scholar 

  4. J. Clarke, W.M. Goubau and M.B. Ketchen, Appl. Phys. Lett. 27, 155(1975).

    Google Scholar 

  5. C.D. Tesche and J. Clarke, J. Low Temp. Phys. 29, 301(1977).

    Google Scholar 

  6. J.E. Zimmerman, J. Appl. Phys. 48, 702(1977).

    Google Scholar 

  7. D. Amaral, in Principles of Neuroscience, edited by E.R. Kandel, J.H. Schwartz and T.M. Jessell, McGraw-Hill, pp. 37-336 (2000).

  8. A.P. Georgopoulos, A.B. Schwartz and R.E. Kettner, Science 233, 1416(1986).

    Google Scholar 

  9. R.R. Llinás and K.D. Walton, in The synaptic organization of the brain, edited by G.M. Shepherd, Oxford University Press, pp. 214-245 (1990).

  10. M. Hämäläinen, R. Hari, R.J. Ilmoniemi, J. Knuutila and O.V. Lounasmaa, Rev. Mod. Phys. 65, 413(1993).

    Google Scholar 

  11. D. Cohen Science 161, 784(1968).

    Google Scholar 

  12. D. Cohen, Science 175, 664(1972).

    Google Scholar 

  13. D. Brenner, S.J. Williamson and L. Kaufman, Science 190, 480(1975).

    Google Scholar 

  14. T.J. Teyler, B.N. Cuffin and D. Cohen, Life Sci. 17, 683(1975).

    Google Scholar 

  15. D. Brenner, S.J. Williamson and L. Kaufman, Science 1999, 81(1978).

    Google Scholar 

  16. D.S. Barth, W. Sutherling, J. Engel Jr., and J. Beatty, Science 218, 891(1982).

    Google Scholar 

  17. W.W. Sutherling, P.H. Crandall, J. Engel Jr., T.M. Darcey, L.D. Cahan and D.S. Barth, Ann. Neurol. 21, 548(1987).

    Google Scholar 

  18. W.W. Sutherling, P.H. Crandall, L.D. Cahan and D.S. Barth, Neurology 38, 778(1988).

    Google Scholar 

  19. N. Forss, J.P. Mäkelä, T. Keranen and R. Hari, NeuroReport 6, 918(1995).

    Google Scholar 

  20. A.I. Ahonen, M.S. Hämäläinen, J.E.T. Knuutila, M.J. Kajola, P.P. Laine, O.V. Lounasmaa, L.T. Parkkonen, J.T. Simola, and C.D. Tesche, Physica Scripta T49, 198(1993).

    Google Scholar 

  21. R. Ilmoniemi, R. Hari and K. Reinikainen, Electroencephalogr. Clin. Neurophysiol. 58, 467(1984).

    Google Scholar 

  22. J.H. Greiner, C.J. Kircher, S.P. Klepner, S.K. Lahiri, A.J. Warnecke, S. Basavaiah, E.T. Yen, J.M. Baker, P.R. Brosious, H.-C.W. Huang, M. Murakami and I. Ames, IBM J. Res. Develop. 24, pp. 195(1980).

    Google Scholar 

  23. J.M. Jaycox and M.B. Ketchen, IEEE Trans. Magn. MAG-17, 400(1981).

    Google Scholar 

  24. B. Cabrera, Phys. Rev. Lett. 48, 1378(1982).

    Google Scholar 

  25. C.D. Tesche, C.C. Chi and C.C. Tsuei and P. Chaudhari, Appl. Phys. Lett. 43, 384(1983).

    Google Scholar 

  26. C.D. Tesche, K.H. Brown, A.C. Callegari, M.M. Chen, J.H. Greiner, H.C. Jones, K.K. Kim, A.W. Kleinsasser, H.A. Notarys, G. Proto, R.H. Wang and T. Yogi in LT-17, U. Eckern, A. Schmid, W.W. Weber, H. Wuhl, eds., Elsevier Science Publishers B.V. (1984).

  27. S. Bermon, P. Chaudhari, C.C. Chi, C.D. Tesche and C.C. Tsuei, Phys. Rev. Lett. 55, 1850(1985).

    Google Scholar 

  28. J. Knuutila, S. Ahlfors, A.I. Ahonen, J. Hällström, M. Kajola, O.V. Lounasmaa, V. Vilkman and C. Tesche, Rev. Sci. Instrum. 58, 2145(1987).

    Google Scholar 

  29. M. Kajola, S. Ahlfors, G.J. Ehnholm, J. Hällström, M.S. Hämäläinen, R.J. Ilmoniemi, M. Kiviranta, J. Knuutila, O.V. Lounasmaa, C.D. Tesche and V. Vilkman, in Advances in Biomagnetism, edited by S.J. Williamson, M. Hoke, G. Stroink and M. Kotani, Plenum, pp. 673(1989).

  30. E. Kaukoranta, R. Hari and O.V. Lounasmaa, Exp. Brain Res. 69, 19(1987).

    Google Scholar 

  31. R. Hari, M. Pelizzone, J.P. Mäkelä, J. Hällström, L. Leinonen and O.V. Lounasmaa, Audiology 26, 31(1987).

    Google Scholar 

  32. R. Aulanko, R. Hari, O.V. Lounasmaa, R. Naatanen and M. Sams, NeuroReport 4, 1356(1993).

    Google Scholar 

  33. M. Vihla, O.V. Lounasmaa and R. Salmelin, Proc. Natl. Acad. Sci. USA 97, 10590(2000).

    Google Scholar 

  34. M. Sams, R. Aulanko, M. Hämäläinen, R. Hari, O.V. Lounasmaa, S.T. Lu,and J. Simola, Neurosci. Lett. 127, 141(1991).

    Google Scholar 

  35. R. Salmelin, R. Hari, O.V. Lounasmaa OV and M. Sams, Nature 368, 463(1994).

    Google Scholar 

  36. O.V. Lounasmaa, M. Hämäläinen, R. Hari and R. Salmelin, Proc. Natl. Acad. Sci. USA 93, 8809(1996).

    Google Scholar 

  37. R. Hari, K. Reinikainen, E. Kaukoranta, M. Hämäläinen, R. Ilmoniemi, A. Penttinen, J. Salminen and D. Teszner, Electroencephalogr. Clin. Neurophysiol. 57, 254(1984).

    Google Scholar 

  38. Y.C. Okada, R. Tanenbaum, S.J. Williamson and L. Kaufman, Exp. Brain Res. 56, 197(1984).

    Google Scholar 

  39. C. Baumgartner, W.W. Sutherling, S. Di and D.S. Barth, Electroencephalogr. Clin. Neurophysiol. 79, 27(1991).

    Google Scholar 

  40. N. Forss, R. Hari, R. Salmelin, A. Ahonen, M. Hämäläinen, M. Kajola, J. Knuutila and J. Simola, Exp. Brain Res. 99, 309(1994).

    Google Scholar 

  41. N. Forss, I. Merlet, S. Vanni, M. Hämäläinen, F. Mauguiere and R. Hari, Brain Res. 734, 229(1996).

    Google Scholar 

  42. A. Korvenoja, H. Wikstrom, J. Huttunen, J. Virtanan, P. Laine, H.J. Aronen, A.M. Seppalainen and R.J. Ilmoniemi, NeuroReport 6, 2589(1995).

    Google Scholar 

  43. A. Schnitzler, R. Salmelin, S. Salenius, V. Jousmaki, and R. Hari, Neurosci Lett. 200, 25-8 (1995).

    Google Scholar 

  44. C. Tesche, NeuroReport 11, 2655(2000).

    Google Scholar 

  45. C. Simoes, O. Jensen, L. Parkkonen and R. Hari, Proc. Natl. Acad. Sci. USA 100, 2691-4 (2003).

    Google Scholar 

  46. M.S. Hämäläinen and J. Sarvas, IEEE Trans. Biomed. Eng. 36, 165(1989).

    Google Scholar 

  47. C.D. Tesche, J. Karhu and S.O. Tissari, Brain Res. Cogn. Brain Res. 4, 39(1996).

    Google Scholar 

  48. M.A. Uusitalo and R.J. Ilmoniemi, Med. Biol. Eng. Comput. 32, 35-42 (1997).

    Google Scholar 

  49. C.D. Tesche, M.A. Uusitalo, R.J. Ilmoniemi, M. Huotilainen, M. Kajola and O. Salonen, Electroencephalogr. Clin. Neurophysiol. 95, 189-200 (1995).

    Google Scholar 

  50. S. Taulu, M. Kajola and J. Simola, Biomed. Tech 48 (in press).

  51. C.D. Tesche, Electroencephalogr. Clin. Neurophysiol. Suppl. 47, 81(1996).

    Google Scholar 

  52. C.D. Tesche and J. Karhu, Brain Res. 744, 23(1997).

    Google Scholar 

  53. H. von Helmholtz, Ann. Phys. Chem. 89, 211, 353 (1853).

    Google Scholar 

  54. K. Uutela, M. Hämäläinen and E. Somersalo, Neuroimage 10, 173(1999).

    Google Scholar 

  55. C. Tesche, T. Martin, J. Houck and R.J. Ilmoniemi, unpublished data.

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Tesche, C.D. SQUIDs from Physics to Brain Research. Journal of Low Temperature Physics 135, 773–791 (2004). https://doi.org/10.1023/B:JOLT.0000029518.63750.14

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