Abstract
A polysaccharide (SFP) extracted from the brown alga Sargassum fusiforme (Harv.) Setch. was purified by chromatography on DEAE-Sephadex A50 and Sephadex G-100. Studies using paper chromatography (PC), electrophoresis and infrared spectroscopy (IR) indicated that SFP was a kind of alginate with a molecular weight of 16 000 and a molar ratio of mannuronic acid (M) to guluronic acid (G) of 2.75. Pharmacological experiments showed that SFP could markedly decrease the content of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) in the serum of experimental hyperlipidemic rats, and significantly increase the level of high density lipoprotein-cholesterol (HDL-C).
Similar content being viewed by others
References
Donnan F. G. & R. C. Rose, 1950. Osmotic pressure, molecular weight, and viscosity of sodium alginate. Can. J. Res. 28B: 105–113.
Haug A., & O. Smidsrod, 1962. Determination of intrinsic viscosity of alginate. Acta Chem. Scand. 16: 1569–1578.
Ji, M. H., 1997. Chemical composition and structure of algin. In Ji, M. H. (ed.), Seaweed Chemistry. Science Press, Beijing: 231–250.
Ji, M. H. & Y. J. Wang, 1984. Studies on the M:G ratios in alginate. Hydrobiologia 116: 554–556.
Ji, M. H., C. Wenda & H. Lijun, 1981. Determination of uronic acid composition of algin. Oceanol. Limnol. Sin. 12: 533–539.
Mackie, W., 1971. Semi-quantitative estimation of the composition of alginates by infrared spectroscopy. Carbohyd. Res. 20: 413–415.
Michio, F., I. Noriko, Y. Ichiro & N. Terukazu, 1984. Purification and chemical and physical characterization of an antitumour polysaccharide from the brown seaweed Sargassum fulvellum. Carbohyd. Res. 125: 97–106.
Moore, W. R., 1975. Viscosity of dilute polymer solutions. Progress in Polymer Science 1: 52–89.
Xu, S. Q., R. L. Bian & X. Chen, 1982. Pharmacology Experiment Methods. Renmin Hygiene Press, Beijing.
Zheng, N. Y., Y. X. Zhang & X. Fan, 1992. Studies on the compositions and sequential structures of uronate residues in alginates from Chinese brown algae Laminaria and Sargassum. Oceanol. Limnol. Sin. 23: 445–452.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mao, W., Li, B., Gu, Q. et al. Preliminary studies on the chemical characterization and antihyperlipidemic activity of polysaccharide from the brown alga Sargassum fusiforme . Hydrobiologia 512, 263–266 (2004). https://doi.org/10.1023/B:HYDR.0000020335.46431.ad
Issue Date:
DOI: https://doi.org/10.1023/B:HYDR.0000020335.46431.ad