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Activation of Pyridinium Salts for Electrophilic Acylation: a Method for Conversion of Pyridines into 3-Acylpyridines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Cyanide adducts of N-MOM pyridinium salts react with strong acylating reagents to provide 3-acyl-4-cyano-1,4-dihydropyridines that can be aromatized to 3-acylpyridines using ZnCl2 in refluxing ethanol.

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Authors and Affiliations

  1. Department of Process Research, Merck Research Laboratories, NJ 07065, USA

    A. Klapars

  2. Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA

    E. Vedejs

Authors
  1. A. Klapars
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  2. E. Vedejs
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Klapars, A., Vedejs, E. Activation of Pyridinium Salts for Electrophilic Acylation: a Method for Conversion of Pyridines into 3-Acylpyridines. Chemistry of Heterocyclic Compounds 40, 759–766 (2004). https://doi.org/10.1023/B:COHC.0000040772.13427.0b

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  • DOI: https://doi.org/10.1023/B:COHC.0000040772.13427.0b

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