Abstract
Microiontophoretic application of melatonin to the perineuronal space of nerve cells in the lateral hypothalamus of WAG and Fischer-344 rats led to decreases in the frequency and regularization of the spike activity of neurons, and also blocked activation of neurons and changing the patterns of adrenaline-induced spike activity. The effects of melatonin were more marked in WAG rats, which demonstrated the more active behavior in the open field test and were predicted to be more resistant to emotional stress, than in passive Fischer-344 rats, with predisposition to emotional stress. These results suggest that the mechanism of the stress-protective action of melatonin involves suppression of the spike activity of neurons in emotiogenic brain structures and changes in their sensitivity to noradrenaline.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
G. A. Gribanov, N. V. Kostyuk, Yu. V. Abramov, L. B. Rebrov, V. A. Bykov, T. V. Volodina, and S. S. Pertsov, “Rat skin lipids after administration of melatonin,” Byull. Éksperim. Biol. Med., 127,No. 4, 463–465 (1999).
S. S. Pertsov, A. S. Sosnovskii, and G. V. Pirogova, “Melatonin and ulcer formation in the stomach in acute emotional stress in rats,” Byull. Éksperim. Biol. Med., No. 1, 12–14 (1998).
K. V. Sudakov, Individual Resistance to Emotional Stress [in Russian], Gorizont, Moscow (1998).
P. Barattini, C. Dolchi, A. Montaruli, E. Roveada, and F. Carandente, “Resynchronization of blood-pressure circadian-rhythm after westward trans-7-meridian flight with and without melatonin treatment,” Aviat. Space Environ. Med., 72,No. 3, 221–224 (2001).
D. Bennathan, G. J. M. Maestroni, S. Lustig, and A. Conti, “Protective effects of melatonin in mice infected with encephalitis viruses,” Arch. Virol., 140,No. 2, 223–230 (1995).
J. E. Drew, P. Barrett, J. G. Mercer, K. M. Moar, E. Canet, P. Delegrange, and P. J. Morgan, “Localization of the melatonin-related receptor in the rodent brain and peripheral tissues,” J. Neuroendocrinol., 13,No. 5, 453–458 (2001).
G. Escames, D. A. Castroviejo, and F. Vives, “Melatonin-dopamine interaction in the striatal projection area of sensorimotor cortex in the rat,” Neuroreport, 7,No. 2, 597–600 (1996).
E. Kuhlwein and M. Irwin, “Melatonin modulation of lymphocyte-proliferation and Th1/Th2 cytokine expression,” J. Neuroimmunol., 117,No. 1–2, 51–57 (2001).
R. Nonno, S. Capsoni, V. Lucini, et al., “Distribution and characterization of the melatonin receptors in the hypothalamus and pituitary gland of 3 domestic ungulates,” J. Pineal Res., 18,No. 4, 207–216 (1995).
G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Fourth Edition, Academic Press, New York (1998).
S. S. Pertsov, “Melatonin: prevention of phase shift in circadian rhythms accompanying drug abuse,” in: Abstracts of the Seventh NIDA International Forum, Quebec City, Canada, June 6–8, 2002 (in press).
R. J. Reiter, D. X. Tan, S. Burkhardt, and L. C. Manchester, “Melatonin in plants,” Nutr. Rev., 59,No. 9, 286–290 (2001).
M. S. Wolfe, N. R. Lee, and M. Zatz, “Properties of clock-controlled and constitutive N-acetyl-transferases from chick pineal cells,” Brain Res., 669,No. 1, 100–106 (1995).
S. W. Ying, B. Rusak, P. Delagrange, E. Mocaer, P. Renard, and B. Guardiolalemaitre, “Melatonin analogs as agonists and antagonists in the circadian system and other brain areas,” Eur. J. Pharmacol., 296,No. 1, 33–42 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pertsov, S.S., Meshcheryakov, A.F., Glushkov, R.G. et al. Spike Activity of Neurons in the Lateral Hypothalamus in Rats During Microiontophoretic Application of Melatonin and Noradrenaline. Neurosci Behav Physiol 34, 479–484 (2004). https://doi.org/10.1023/B:NEAB.0000022633.73030.24
Issue Date:
DOI: https://doi.org/10.1023/B:NEAB.0000022633.73030.24