Abstract
Herein we describe the conversion of a known [3+2] cycloaddition reaction between an azide and an acetylene from a thermally promoted reaction to a microwave assisted process. Modification of conditions including concentration, temperature, solvent type and time were investigated. This methodology study led us to use high concentration and high temperatures to achieve the desired fast reaction times and high yields.
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Savin, K.A., Robertson, M., Gernert, D. et al. A study of the synthesis of triazoles using microwave irradiation. Mol Divers 7, 171–174 (2003). https://doi.org/10.1023/B:MODI.0000006801.27748.3b
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DOI: https://doi.org/10.1023/B:MODI.0000006801.27748.3b