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The gender differences in health effects of environmental cadmium exposure and potential mechanisms

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Abstract

On a viewpoint of gender differences in Cd body burden and its health effects, we reviewed the population-based research including our own which conducted in Japan, Thailand, Australia, Poland, Belgium and Sweden to assess health effects of human exposure to environmental cadmium and their potential mechanisms. As a result, six risk factors in Cd health effects in women have been identified; (1) more serious type of renal tubular dysfunction, (2) difference in calcium metabolism and its regulatory hormones, (3) kidney sensitivity; difference in P450 phenotype, (4) pregnancy, (5) body iron store status, and (6) genetic factors. Further studies of Cd toxicity targeted to women would now appear necessary.

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Authors and Affiliations

  1. Department of Public Health, Kanazawa Medical University, Japan

    Muneko Nishijo

  2. National Research Center for Environmental Toxicology, Brisbane, Australia

    Soisungwan Satarug

  3. Department of Hygiene, Kanazawa Medical University, Japan

    Ryumon Honda, Ikiko Tsuritani & Keiko Aoshima

Authors
  1. Muneko Nishijo
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  2. Soisungwan Satarug
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  3. Ryumon Honda
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  4. Ikiko Tsuritani
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  5. Keiko Aoshima
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Nishijo, M., Satarug, S., Honda, R. et al. The gender differences in health effects of environmental cadmium exposure and potential mechanisms. Mol Cell Biochem 255, 87–92 (2004). https://doi.org/10.1023/B:MCBI.0000007264.37170.39

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  • DOI: https://doi.org/10.1023/B:MCBI.0000007264.37170.39

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