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Effect of Lupus Anticoagulant on the Interaction of Prothrombin with Platelets

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Abstract

We studied binding of 125I-labeled prothrombin to platelets in the presence of circulating endogenous lupus anticoagulant. Lupus anticoagulant modulated the interaction and increased affinity of prothrombin for calcium-independent binding sites on platelets. The number of these sites decreased, while the total number of calcium-dependent binding sites increased. Our results indicate that lupus anticoagulant plays a role in the binding of prothrombin to nonactivated platelets.

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Authors and Affiliations

  1. Kazan State Medical University, Russia

    S. V. Kiselev, D. M. Zubairov, I. A. Andrushko & Yu. L. Katsadze

Authors
  1. S. V. Kiselev
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  2. D. M. Zubairov
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  3. I. A. Andrushko
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  4. Yu. L. Katsadze
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Kiselev, S.V., Zubairov, D.M., Andrushko, I.A. et al. Effect of Lupus Anticoagulant on the Interaction of Prothrombin with Platelets. Bulletin of Experimental Biology and Medicine 137, 538–540 (2004). https://doi.org/10.1023/B:BEBM.0000042705.59356.05

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  • DOI: https://doi.org/10.1023/B:BEBM.0000042705.59356.05

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