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Invasive Characteristics of Apathogenic Shigella flexneri 5a2c Mutant Obtained under the Effect of Furazolidone

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Abstract

Apathogenic Shigella flexneri 5a2c mutant treated with furazolidone can infect eucaryotic cells. These bacteria contain no virulence genes responsible for Sh. Flexneri invasion, which seems to be the cause of their apathogenicity. The capacity of bacteria to penetrate into eucaryotic cells correlates with the appearance of ECP 32 protease specifically cleaving actin.

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REFERENCES

  1. T. N. Efremova, N. A. Ender, M. S. Brudnaya, et al., Tsitologiya, 40, No. 6, 524–528 (1988).

    Google Scholar 

  2. T. Maniatis, E. Frich, and J. Sambrook, Methods of Genetic Engineering. Molecular Cloning [in Russian], Moscow (1984).

  3. Z. F. Fedorova, Antibiotiki, No. 7, 527–531 (1982).

  4. Z. F. Fedorova and S. Yu. Khaitlina, Byull. Eksp. Biol. Med., 110, No. 7, 46–48 (1990).

    Google Scholar 

  5. C. Buchrieser, P. Glaser, C. Rusniok, et al., Mol. Microbiol., 38, 1–14 (2000).

    Google Scholar 

  6. T. Efremova, N. Ender, M. Brudnaja, et al., Cell. Biol. Int., 25, 557–561 (2001).

    Google Scholar 

  7. M. B. Goldberg, O. Barzu, C. Parsot, and P. J. Sansonetti, J. Bacteriol., 175, 2189–2196 (1993).

    Google Scholar 

  8. S. Yu. Khaitlina, J. H. Collins, I. M. Kuznetsova, et al., FEBS Lett., 279, 49–51 (1991).

    Google Scholar 

  9. I. Lasa and P. Cossart, Trends Cell Biol., 6, 109–114 (1996).

    Google Scholar 

  10. R. Menard, P. J. Sansonetti, and C. Parsot, J. Bacteriol., 75, 5899–5906 (1993).

    Google Scholar 

  11. I. Rosenshine and B. B. Finlay, Bioessays, 15, No. 1, 17–24 (1993).

    Google Scholar 

  12. P. J. Sansonetti, Rev. Infect. Dis., 13, Suppl. 14, 287–292 (1991).

    Google Scholar 

  13. P. J. Sansonetti, FEMS Microbiol. Review, 25, 3–14 (2001).

    Google Scholar 

  14. R. Schuch and A. T. Maurelli, Infect. Immun., 65, 3687–3692 (1997).

    Google Scholar 

  15. J. Theriot, Annu. Rev. Cell Dev. Biol., 11, 213–239 (1995).

    Google Scholar 

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Authors and Affiliations

  1. Department of Cell Cultures, Institute of Cytology, Russian Academy of Sciences, St. Petersburg

    T. N. Efremova, I. G. Gruzdeva, I. V. Matveev, E. S. Bozhokina, Ya. Yu. Komissarchuk, Z. F. Fedorova & S. Yu. Khaitlina

  2. Department of Microbiology, I. P. Pavlov St. Petersburg Medical University, Russia

    T. N. Efremova, I. G. Gruzdeva, I. V. Matveev, E. S. Bozhokina, Ya. Yu. Komissarchuk, Z. F. Fedorova & S. Yu. Khaitlina

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  1. T. N. Efremova
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  2. I. G. Gruzdeva
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  3. I. V. Matveev
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  4. E. S. Bozhokina
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  5. Ya. Yu. Komissarchuk
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  6. Z. F. Fedorova
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  7. S. Yu. Khaitlina
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Efremova, T.N., Gruzdeva, I.G., Matveev, I.V. et al. Invasive Characteristics of Apathogenic Shigella flexneri 5a2c Mutant Obtained under the Effect of Furazolidone. Bulletin of Experimental Biology and Medicine 137, 479–482 (2004). https://doi.org/10.1023/B:BEBM.0000038158.27725.41

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  • DOI: https://doi.org/10.1023/B:BEBM.0000038158.27725.41

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