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Effect of M4-Cholinoceptor Blockade on Haloperidol-Produced Catatonic Syndrome in Rats

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Abstract

We studied the relationship between the efficiency of muscarinic receptor antagonists in preventing haloperidol-induced catatonia and their activity in tests for the interaction of ligands with various subtypes of muscarinic receptors (M1-M4) in rats. Mathematical modeling showed that affinity of the ligand for M4 receptors positively affects its ability to correct extrapyramidal disorders (catatonic syndrome) produced by haloperidol, while affinity for M2 receptors had a negative effect on this characteristic.

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Dagaev, S.G., Kosmachev, A.B., Fil'ko, O.A. et al. Effect of M4-Cholinoceptor Blockade on Haloperidol-Produced Catatonic Syndrome in Rats. Bulletin of Experimental Biology and Medicine 137, 152–154 (2004). https://doi.org/10.1023/B:BEBM.0000028127.58625.f0

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  • DOI: https://doi.org/10.1023/B:BEBM.0000028127.58625.f0

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