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Combined Action of Doxorubicin and Gestagens on Doxorubicin-Sensitive and Doxorubicin-Resistant MCF-7 Cells

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Abstract

The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecigestone, and butagest in high concentrations (10-5 M) potentiated the cytostatic action of doxorubicin in sensitive and resistant cells by 30-50%. Potentiation of the cytostatic effect produced by doxorubicin in sensitive cells is related to intrinsic cytotoxic activity of gestagens. In resistant cells these changes are associated with potentiation of the effect of doxorubicin.

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REFERENCES

  1. P. V. Sergeev, A. V. Semeikin, and T. A. Fedotcheva, Vopr. Biol. Med. Farm. Khimii, No. 3, 10-17 (2002).

  2. Federal Manual on the Use of Medicinal Preparations [in Russian], No. 3, 733-735 (2002).

  3. N. L. Shimanovskii, A. V. Semeikin, and T. A. Fedotcheva, Byull. Eksp. Biol. Med., 134, No. 10, 447-450 (2002).

    Google Scholar 

  4. J. A. Claudio and J. T. Emerman, Breast Cancer Res. Treat., 41, No. 2, 111-122 (1996).

    Google Scholar 

  5. R. T. Dorr and J. D. Liddil, Cancer Chemother. Pharmacol., 27, No. 4, 290-294 (1991).

    Google Scholar 

  6. L. A. Doyle, W. Yang, and L. V. Abruzzo, Proc. Natl. Acad. Sci. USA, 95, No. 26, 15,665-15,670 (1998).

    Google Scholar 

  7. M. Garrios, L. M. Mir, and S. Orlowsky, Eur. J. Biochem., 244, 664-673 (1997).

    Google Scholar 

  8. J. Li, L. Z. Xu, and K. L. He, Breast Cancer Res., 3, No. 4, 253-263 (2001).

    Google Scholar 

  9. K. L. Mealey, R. Barhoumi, and R. C. Burghardt, Antimicrob. Agents Chemother., 46, No. 3, 755-761 (2002).

    Google Scholar 

  10. A. Seeling, Eur. J. Biochem., 251, Nos. 1-2, 252-261 (1998).

    Google Scholar 

  11. P. Wielinga, H. Westerhoff, and J. Lankelma, Eur. J. Biochem., 267, 649-657 (2000).

    Google Scholar 

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Radiobiology, Medical and Biological Faculty, Russian State Medical University, Russia

    P. V. Sergeev, A. V. Semeikin, T. A. Fedotcheva, R. V. Samoilikov, A. V. Kamernitskii, I. S. Levina, V. M. Rzheznikov, G. S. Grinenko, Yu. N. Korystov, N. V. Ermakova, V. V. Shaposhnikova & N. L. Shimanovskii

  2. Group for Chemistry of Steroids and Oxylipins, N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow

    P. V. Sergeev, A. V. Semeikin, T. A. Fedotcheva, R. V. Samoilikov, A. V. Kamernitskii, I. S. Levina, V. M. Rzheznikov, G. S. Grinenko, Yu. N. Korystov, N. V. Ermakova, V. V. Shaposhnikova & N. L. Shimanovskii

  3. Research Center for Endocrinology, Russian Academy of Medical Sciences, Moscow

    P. V. Sergeev, A. V. Semeikin, T. A. Fedotcheva, R. V. Samoilikov, A. V. Kamernitskii, I. S. Levina, V. M. Rzheznikov, G. S. Grinenko, Yu. N. Korystov, N. V. Ermakova, V. V. Shaposhnikova & N. L. Shimanovskii

  4. Laboratory for Regulation of Cell Proliferation and Death, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino

    P. V. Sergeev, A. V. Semeikin, T. A. Fedotcheva, R. V. Samoilikov, A. V. Kamernitskii, I. S. Levina, V. M. Rzheznikov, G. S. Grinenko, Yu. N. Korystov, N. V. Ermakova, V. V. Shaposhnikova & N. L. Shimanovskii

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  1. P. V. Sergeev
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  2. A. V. Semeikin
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  3. T. A. Fedotcheva
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  4. R. V. Samoilikov
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  5. A. V. Kamernitskii
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  6. I. S. Levina
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  7. V. M. Rzheznikov
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  8. G. S. Grinenko
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  9. Yu. N. Korystov
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  10. N. V. Ermakova
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  11. V. V. Shaposhnikova
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  12. N. L. Shimanovskii
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Sergeev, P.V., Semeikin, A.V., Fedotcheva, T.A. et al. Combined Action of Doxorubicin and Gestagens on Doxorubicin-Sensitive and Doxorubicin-Resistant MCF-7 Cells. Bulletin of Experimental Biology and Medicine 136, 460–463 (2003). https://doi.org/10.1023/B:BEBM.0000017093.04390.a3

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  • DOI: https://doi.org/10.1023/B:BEBM.0000017093.04390.a3

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