Skip to main content
SpringerLink
Log in

Optimized Individual Mismatch Negativity Source Localization Using a Realistic Head Model and the Talairach Coordinate System

  • Published:
Brain Topography Aims and scope Submit manuscript

Abstract

The purpose of this study is to evaluate the difference between anatomical locations of mismatch negativity (MMN) generators using a realistic head model and the Talairach coordinate system. This was performed by dipole source analysis by using a high density 128 channel electroencephalography (EEG) acquisition system and the subjects' individual 3D magnetic resonance images (MRI) for the realistic head model, in 24 healthy subjects. For dipole source localization, both the Talairach coordinate system and the individual MRI realistic head models were used and location results were compared. The MMN generators were clearly localized in the superior temporal gyri, especially in Heschl's gyrus, according to each individual's structural MRI. Only 37.5% of subjects showed the same anatomical locations of the MMN generator in both hemispheres in the realistic head model and in Talairach coordinate system, but fifteen subjects (62.5%) didn't. This result indicates that individually registered functional locations are desirable for the precise localization of activated areas in functional imaging studies and that a brain coordinate system is needed which adequately accounts for ethnic differences.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ackermann, H., Lutzenberger, W. and Hertrich, I. Hemispheric lateralization of the neural encoding of temporal speech features: a whole-head magnetencephalography study. Brain Res. Cogn. Brain Res., 1999, 7: 511-518.

    PubMed  Google Scholar 

  • Alho, K., Connolly, J.F., Cheour, M., Lehtokoski, A., Huotilainen, M., Virtanen, J., Aulanko, R. and Ilmoniemi, R.J. Hemispheric lateralization in preattentive processing of speech sounds. Neurosci. Lett., 1998a, 258: 9-12.

    PubMed  Google Scholar 

  • Alho, K., Winkler, I., Escera, C., Huotilainen, M., Virtanen, J., Jaaskelainen, I.P., Pekkonen, E. and Ilmoniemi, R.J. Processing of novel sounds and frequency changes in the human auditory cortex: magnetoencephalographic recordings. Psychophysiology, 1998b, 35: 211-224.

    PubMed  Google Scholar 

  • Boon, P., D'Have, M., Vanrumste, B., Van Hoey, G., Vonck, K., Van Walleghem, P., Caemaert, J., Achten, E. and De Reuck, J. Ictal source localization in presurgical patients with refractory epilepsy. J. Clin. Neurophysiol., 2002, 19: 461-468.

    PubMed  Google Scholar 

  • Buchner, H., Waberski, T.D., Fuchs, M., Wischmann, H.A., Wagner, M. and Drenckhahn, R. Comparison of realistically shaped boundary-element and spherical head models in source localization of early somatosensory evoked potentials. Brain Topogr., 1995, 8: 137-143.

    PubMed  Google Scholar 

  • Cuffin, B.N. EEG dipole source localization. IEEE Eng. Med. Biol. Mag., 1998, 117: 118-122.

    Google Scholar 

  • Deouell, L.Y., Bentin, S. and Giard, M.H. Mismatch negativity in dichotic listening: evidence for interhemispheric differences and multiple generators. Psychophysiology, 1998, 35: 355-365.

    PubMed  Google Scholar 

  • Fox, P.T. Spatial normalization: origins, objectives, applications and alternatives. Hum.Brain Mapp., 1995, 3: 161-164.

    Google Scholar 

  • Fuchs, M., Drenckhahn, R., Wischmann, H.A. and Wagner, M. An improved boundary element method for realistic volume-conductor modeling. IEEE Trans. Biomed. Eng., 1998, 45: 980-997.

    PubMed  Google Scholar 

  • Gevins, A. The future of electroencephalography in assessing neurocognitive functioning. Electroencephalogr. Clin. Neurophysiol., 1998, 106: 165-172.

    PubMed  Google Scholar 

  • Giard, M.H., Perrin, F., Pernier, J. and Bouchet, P. Brain generators implicated in the processing of auditory stimulus deviance: a topographic event-related potential study. Psychophysiology, 1990, 27: 627-640.

    PubMed  Google Scholar 

  • Han, S., Fan, S., Chen, L. and Zhuo, Y. Modulation of brain activities by hierarchical processing: a high-density ERP study. Brain Topogr., 1999, 11: 171-183.

    PubMed  Google Scholar 

  • Hari, R., Hamalainen, M., Ilmoniemi, R., Kaukoranta, E., Reinikainen, K., Salminen, J., Alho, K., Näätänen, R. and Sams, M. Responses of the primary auditory cortex to pitch changes in a sequence of tone pips: neuromagnetic recordings in man. Neurosci. Lett., 1984, 50: 127-132.

    PubMed  Google Scholar 

  • Jemel, B., Achenbach, C., Muller, B.W., Ropcke, B. and Oades, R.D. Mismatch negativity results from bilateral asymmetric dipole sources in the frontal and temporal lobes. Brain Topogr., 2002, 15: 13-27.

    PubMed  Google Scholar 

  • Kaiser, J. and Lutzenberger, W. Location changes enhance hemispheric asymmetry of magnetic fields evoked by lateralized sounds in humans. Neurosci. Lett., 2001, 314: 17-20.

    PubMed  Google Scholar 

  • Kasai, K., Nakagome, K., Itoh, K., Koshida, I., Hata, A., Iwanami, A., Fukuda, M., Hiramatsu, K.I. and Kato, N. Multiple generators in the auditory automatic discrimination process in humans. Neuroreport, 1999, 10: 2267-2271.

    PubMed  Google Scholar 

  • Kreitschmann-Andermahr, I., Rosburg, T., Meier, T., Volz, H.P., Nowak, H. and Sauer, H. Impaired sensory processing in male patients with schizophrenia: a magnetoencephalographic study of auditory mismatch detection. Schizophr Res, 1999, 35: 121-129.

    PubMed  Google Scholar 

  • Laarne, P.H., Tenhunen-Eskelinen, M.L., Hyttinen, J.K. and Eskola, H.J. Effect ofEEGelectrode density on dipole localization accuracy using two realistically shaped skull resistivity models. Brain Topogr., 2000, 12: 249-254.

    PubMed  Google Scholar 

  • Lancaster, J.L., Rainey, L., Summerlin, J.L., Freitas, C.S., Fox, P.T., Evans, A.E., Toga, A.W. and Mazziotta, J.C. Automated labeling of the human brain: A preliminary report on the development and evaluation of a forward-transform method.Hum. Brain Mapp., 1997, 5: 238-242.

    Google Scholar 

  • Lancaster, J.L., Woldorff, M.G., Parsons, L.M., Liotti, M., Freitas, C.S., Rainey, L., Kochunov, P.V., Nickerson, D., Mikiten, S.A. and Fox, P.T. Automated Talairach atlas labels for functional brain mapping. Hum. Brain Mapp., 2000, 10: 120-131.

    PubMed  Google Scholar 

  • Näätänen, R. Mismatch negativity (MMN): perspectives for application. Int. J. Psychophysiol., 2000, 37: 3-10.

    PubMed  Google Scholar 

  • Näätänen, R., Gaillard, A.W. and Mantysalo, S. Early selective-attention effect on evoked potential reinterpreted. Acta. Psychol. (Amst.), 1978, 42: 313-329.

    Google Scholar 

  • Näätänen, R., and Michie, P.T. Early selective-attention effects on the evoked potential: a critical review and reinterpretation. Biol. Psychol., 1979, 8: 81-136.

    PubMed  Google Scholar 

  • Park, H.J., Kwon, J.S., Youn, T., Pae, J.S., Kim, J.J., Kim, M.S. and Ha, K.S. Statistical parametric mapping of LORETA using high density EEG and individual MRI: application to mismatch negativities in schizophrenia. Hum. Brain Mapp., 2002, 17: 168-178.

    PubMed  Google Scholar 

  • Rinne, T., Alho, K., Ilmoniemi, R.J., Virtanen, J. and Näätänen, R. Separate time behaviors of the temporal and frontal mismatch negativity sources. Neuroimage, 2000, 12: 14-19.

    PubMed  Google Scholar 

  • Scherg, M., Picton, T.W. and Vajsar, J. A source analysis of the human auditory evoked potentials. J. Cogn. Neurosci., 1989, 1: 336-355.

    Google Scholar 

  • Scherg, M. and Von Cramon, D.Two bilateral sources of the late AEP as identified by a spatio-temporal dipole model. Electroencephalogr. Clin. Neurophysiol., 1985, 62: 32-44.

    PubMed  Google Scholar 

  • Talairach, J. and Tournoux, P. Co-Planar Stereotaxic Atlas of the Human Brain. Verlag; Stuttgart: Thieme, 1988.

    Google Scholar 

  • Waberski, T.D., Buchner, H., Lehnertz, K., Hufnagel, A., Fuchs, M., Beckmann, R. and Rienacker, A. Properties of advanced head modelling and source reconstruction for the localization of epileptiform activity. Brain Topogr., 1998, 10: 283-290.

    PubMed  Google Scholar 

  • Waberski, T.D., Kreitschmann-Andermahr, I., Kawohl, W., Darvas, F., Ryang, Y., Gobbele, R. and Buchner, H. Spatio-temporal source imaging reveals subcomponents of the human auditory mismatch negativity in the cingulum and right inferior temporal gyrus. Neurosci. Lett., 2001, 308: 107-110.

    PubMed  Google Scholar 

  • Youn, T., Park, H.J., Kim, J.J., Kim, M.S. and Kwon, J.S. Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity. Schizophr. Res., 2003, 59: 253-260.

    PubMed  Google Scholar 

  • Zilles, K., Kawashima, R., Dabringhaus, A., Fukuda, H. and Schormann, T. Hemispheric shape of European and Japanese brains: 3-D MRI analysis of intersubject variability, ethnical, and gender differences. Neuroimage, 2001, 13: 262-271.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry,, Seoul National University College of Medicine,, Seoul,, South Korea

    Kyoo Seob Ha, Tak Youn & Seog Weon Kong

  2. BK 21 Human Life Sciences,, Seoul National University College of Medicine,, Seoul,, South Korea

    Hae-Jeong Park, Tae Hyon Ha, Myung Sun Kim & Jun Soo Kwon

  3. Department of Psychiatry,, Seoul National University College of Medicine,, Seoul,, South Korea

    Tae Hyon Ha & Jun Soo Kwon

Authors
  1. Kyoo Seob Ha
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tak Youn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Seog Weon Kong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hae-Jeong Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tae Hyon Ha
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Myung Sun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jun Soo Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ha, K.S., Youn, T., Kong, S.W. et al. Optimized Individual Mismatch Negativity Source Localization Using a Realistic Head Model and the Talairach Coordinate System. Brain Topogr 15, 233–238 (2003). https://doi.org/10.1023/A:1023910108759

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1023910108759

Search

Navigation