Abstract
We describe an 18-year-old male with an intramedullary spinal cord germinoma in whom the diagnosis was made two years after onset of a progressive myelopathy. Spinal cord germinomas are rare, most having been described in young Japanese adults. They often respond well to radiotherapy. A unique feature of this case was the prolonged time interval between onset of the patient's symptoms and ability to visualize the mass radiographically. A further interesting finding was the infiltrative nature of the tumor surrounding residual spinal cord neurons.
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Horowitz M, Hall W: Central nervous system germinomas. Arch Neurol 48: 652-657, 1991
Balmaceda C: Chemotherapy for intramedullary spinal cord tumors. J Neuro-Oncol 47: 293-307, 2000
Ganslandt O, Buchfelder M, Grabenbauer G: Primary spinal germinoma in a patient with concomitant Klinefelter's syndrome. Br J Neurosurg 14: 252-255, 2000
Hisa S, Morinaga S, Kobayashi Y, Ojima M, Chikaoka H, Sasano N: Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy. Cancer 55: 2845-2849, 1985
Horvath L, McDowell D, Stevens G, Parkinson R, McCarthy S, Boyer M: Unusual presentation of germ cell tumors. J Clin Oncol 19: 911-915, 2001
Itoh Y, Mineura K, Sasajima H, Kowada M: Intramedullary spinal cord germinoma: case report and review of the literature. Neurosurg 38: 187-191, 1996
Kiyuna M, Toda T, Sadi A, Toyoda Z, Nakashima Y: Case report: a rare case of extramedullary spinal cord germinoma. Path Int 49: 633-637, 1999
Matsuoka S, Itoh M, Shinonome T, Tanimura A: Intramedullary spinal cord germinoma: case report. Surg Neurol 35: 122-126, 1991
Matsuyama Y, Nagasaka T, Mimatsu K, Inoue K, Mii K, Iwata H: Intramedullary spinal cord germinoma. Spine 20: 2338-2340, 1995
Miyauchi A, Matsumoto K, Kohmura E, Doi T, Hashimoto K, Kawano K: Primary intramedullary spinal cord germinoma: case report. J Neurosurg 84: 1060-1061, 1996
Nagasawa S, Kikuchi H, Yamashita J, Mitsuno K: Intracranial and spinal germinomas occuring four years after spinal cord germinoma. Neurol Med Chir (Tokyo) 31: 729-731, 1991
Slagel D, Goeken J, Platz C, Moore S: Primary germinoma of the spinal cord: a case report with 28-year follow-up and review of the literature. Acta Neuropathol 90: 657-659, 1995
Bjornsson J, Scheithauer BW, Okazaki H, Leech R: Intracranial germ cell tumors: pathobiological and immunohistochemical aspects of 70 cases. J Neuropath Exp Neurol 44: 32-46, 1985
Bamberg M, Kortmann R, Calaminus G, Becker G, Meisner C, Harms D, Göbel U: Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol 17: 2585-2592, 1999
Haddock M, Schild S, Scheithauer BW, Schomberg P: Radiation therapy for histologically confirmed primary central nervous system germinoma. Int J Rad Oncol Biol Phys 38: 915-923, 1997
Shirato H, Nishio M, Sawamura Y, Myohjin M, Kitahara T, Nishioka T, Mizutani Y, Abe H, Miysaka K: Analysis of long-term treatment of intracranial germinoma. Int J Rad Oncol Biol Phys 37: 511-515, 1997
Wolden S, Wara W, Larson D, Prados M, Edwards M, Sneed P: Radiation therapy for primary intracranial germcell tumors. Int J Rad Oncol Biol Phys 32: 943-949, 1995
Aoyama H, Shirato H, Ikeda J, Fujieda K, Miyasaka K, Sawamura Y: Induction chemotherapy followed by lowdose involved-field radiotherapy for intracranial germ cell tumors. J Clin Oncol 20: 857-865, 2002
Hanafusa K, Shibuya H, Yamaura A, Suzuki S: Intramedullary spinal cord germinoma: case report and review of the literature. Fortschr Rontgenstr 159: 203-204, 1993
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Chute, D.J., Burton, E.C., Klement, I.A. et al. Primary Intramedullary Spinal Cord Germinoma: Case Report. J Neurooncol 63, 69–73 (2003). https://doi.org/10.1023/A:1023789806797
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DOI: https://doi.org/10.1023/A:1023789806797