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Starburst Conjugates of Proteins with Carbon-Chain Polymers Containing Low Molecular Biologically Active Compounds: Synthesis and Immunogenicity

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Abstract

The synthesis of starburst polymer–protein conjugates on the basis of bovine serum albumin and horseradish peroxidase was performed with the aim to study the possibilities of regulation of the immune response against the components of the conjugates. These polymers had one-point binding between the protein and the modifying carbon-chain polymer that contained 1-vinyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (a salsolinol analogue) or bradykinin (peptide hormone) residues in its carbon chain. Changes in the chemical nature of the carbon-chain part of the polymer–protein conjugate were shown to increase or decrease the level of antibody production both against the low-molecular compounds attached to the polymeric fragments and against the protein carrier.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bol'shoi prosp. 31, St. Petersburg, 199004, Russia

    G. P. Vlasov, G. A. Pankova, I. N. Nikonova & N. G. Antonov

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  1. G. P. Vlasov
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  2. G. A. Pankova
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  3. I. N. Nikonova
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  4. N. G. Antonov
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Correspondence to G. P. Vlasov.

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Vlasov, G.P., Pankova, G.A., Nikonova, I.N. et al. Starburst Conjugates of Proteins with Carbon-Chain Polymers Containing Low Molecular Biologically Active Compounds: Synthesis and Immunogenicity. Russian Journal of Bioorganic Chemistry 29, 33–43 (2003). https://doi.org/10.1023/A:1022226418497

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