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NO-Inhibiting and Vasotropic Activity of Some Compounds with Thioamidine Group

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Abstract

Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endotoxin-treated mice. Injection of these agents to anesthetized rats increased arterial pressure and enhanced respiration rate. This effect probably reflects inhibition of not only inducible, but also the constitutive synthesis of NO by compounds with thioamidine group.

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Authors and Affiliations

  1. Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk

    S. Ya. Proskuryakov, N. G. Kucherenko, A. I. Trishkina, M. V. Filimonova, A. G. Shevchuk, L. V. Shtein, Yu. G. Verkhovskii, A. G. Konoplyannikov, A. A. Mandrugin, V. M. Fedoseev & V. G. Skvortsov

  2. Department of Chemistry, M. V. Lomonosov Moscow State University, Russia

    S. Ya. Proskuryakov, N. G. Kucherenko, A. I. Trishkina, M. V. Filimonova, A. G. Shevchuk, L. V. Shtein, Yu. G. Verkhovskii, A. G. Konoplyannikov, A. A. Mandrugin, V. M. Fedoseev & V. G. Skvortsov

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  1. S. Ya. Proskuryakov
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  2. N. G. Kucherenko
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  3. A. I. Trishkina
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  4. M. V. Filimonova
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  5. A. G. Shevchuk
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  6. L. V. Shtein
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  7. Yu. G. Verkhovskii
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  8. A. G. Konoplyannikov
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  9. A. A. Mandrugin
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  10. V. M. Fedoseev
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  11. V. G. Skvortsov
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Proskuryakov, S.Y., Kucherenko, N.G., Trishkina, A.I. et al. NO-Inhibiting and Vasotropic Activity of Some Compounds with Thioamidine Group. Bulletin of Experimental Biology and Medicine 134, 338–341 (2002). https://doi.org/10.1023/A:1021943811672

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  • DOI: https://doi.org/10.1023/A:1021943811672

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