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Modelling Inter-Segmental Coordination of Neuronal Oscillators: Synaptic Mechanisms for Uni-Directional Coupling During Swimming in Xenopus Tadpoles

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Abstract

Locomotion requires longitudinal co-ordination. We have examined uni-directional synaptic coupling processes between two classes of neuronal network oscillators: autonomously active “intrinsic” oscillators, and “potential” oscillators that lack sufficient excitatory drive for autonomous activity. We model such oscillator networks in the bilaterally-symmetrical, Xenopus tadpole spinal cord circuits that co-ordinate swimming. “Glutamate” coupling EPSPs can entrain a second oscillator of lower frequency provided their strength is sufficient. Fast (AMPA) EPSPs advance spiking on each cycle, while slow (NMDA) EPSPs increase frequency over many cycles. EPSPs can also enable rhythmicity in “potential” oscillators and entrain them. IPSPs operate primarily on a cycle-by-cycle basis. They can advance or delay spiking to entrain a second “intrinsic” oscillator with higher, equal or lower frequency. Bilaterally symmetrical coupling connections operate twice per cycle: once in each half-cycle, on each side of the receiving oscillator. Excitatory and inhibitory coupling allow entrainment in complimentary areas of parameter space.

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Authors and Affiliations

  1. School of Biological Sciences, University of Bristol, Bristol, BS8 1UG, UK

    Mark J. Tunstall, Alan Roberts & S.R. Soffe

  2. Department of Anatomy and Structural Biology, University of Otago Medical School, P.O. Box 913, Dunedin, New Zealand

    Mark J. Tunstall

Authors
  1. Mark J. Tunstall
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  2. Alan Roberts
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  3. S.R. Soffe
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Tunstall, M.J., Roberts, A. & Soffe, S. Modelling Inter-Segmental Coordination of Neuronal Oscillators: Synaptic Mechanisms for Uni-Directional Coupling During Swimming in Xenopus Tadpoles. J Comput Neurosci 13, 143–158 (2002). https://doi.org/10.1023/A:1020114324350

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  • DOI: https://doi.org/10.1023/A:1020114324350

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