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The potential role of sialoadhesin as a macrophage recognition molecule in health and disease

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Abstract

Sialoadhesin is a macrophage-restricted transmembrane glycoprotein of 185 kDa that mediates cell–cell interactions through recognition of Neu5Acα2,3Gal in glycoconjugates. The extracellular region of sialoadhesin is composed of seventeen immunoglobulin-like domains, of which the amino-terminal two are highly-related structurally and functionally to the amino-terminal domains of CD22, myelin associated glycoprotein and CD33. These proteins, collectively known as the sialoadhesin family, are able to mediate sialic acid-dependent binding with distinct specificities for both the type of sialic acid and its linkage to subterminal sugars. In this review we discuss our recent studies on sialoadhesin and suggest how this molecule may contribute to a range of macrophage functions, both under normal conditions as well as during inflammatory reactions. Abbreviations: Ig, immunoglobulin; CEA, carcinoembryonic antigen; MAG, myelin associated glycoprotein; SMP Schwann cell myelin protein; mAb, monoclonal antibody; Chinese hamster ovary (CHO); UTR, untranslated region

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References

  1. Gordon S (1995) BioEssays 17: 977–86.

    Article  PubMed  CAS  Google Scholar 

  2. Metchnikoff E (1893) Lectures on the Comparitive Pathology of Inßammation; London, Kegan Paul, Trench, Truber & Co.

    Google Scholar 

  3. Savill J, Fadok V, Henson P, Haslett C (1993) Immunol Today 14: 131–36.

    Article  PubMed  CAS  Google Scholar 

  4. Drickamer K, Taylor ME (1993) Annu Rev Cell Biol 9: 237–64.

    Article  PubMed  CAS  Google Scholar 

  5. Crocker PR, Gordon S (1986) J Exp Med 164: 1862–75.

    Article  PubMed  CAS  Google Scholar 

  6. Crocker PR, Gordon S (1989) J Exp Med 169: 1333–46.

    Article  PubMed  CAS  Google Scholar 

  7. Crocker PR, Kelm S, Dubois C, Martin B, McWilliam AS, Shotton DM, Paulson JC, Gordon S (1991) EMBO J 10: 1661–69.

    PubMed  CAS  Google Scholar 

  8. Crocker PR, Mucklow S, Bouckson V, McWilliam A, Willis AC, Gordon S, Milon G, Kelm S, BradÞeld P (1994) EMBO J 13: 4490–503.

    PubMed  CAS  Google Scholar 

  9. Mucklow S (1996) D Phil Thesis, Oxford University.

  10. Rudert F, Saunders AM, Rebstock S, Thompson JA, Zimmermann W (1992) Mammal Gen 3: 262–73.

    Article  CAS  Google Scholar 

  11. Kelm S, Pelz A, Schauer R, Filbin MT, Tang S, Bellard M-Ed, Schnaar RL, Mahoney JA, Hartnell A, BradÞeld P, Crocker PR (1994) Curr Biol 4: 965–72.

    Article  PubMed  CAS  Google Scholar 

  12. Powell LD, Varki A (1995) J Biol Chem 270: 14243–46.

    Article  PubMed  CAS  Google Scholar 

  13. Crocker PR, Kelm S, Hartnell A, Freeman S, Nath D, Vinson M, Mucklow S (1996) Biochem Soc Trans 24: 149–56.

    Google Scholar 

  14. Kelm S, Schauer R, Crocker PR (1996) Glycoconj J 13: 913–26.

    Article  PubMed  CAS  Google Scholar 

  15. Williams AF, Davis SJ, He Q, Barclay AN (1989) Cold Spring Harbor Symp Quant Biol 54: 637–47.

    PubMed  CAS  Google Scholar 

  16. Crocker PR, Freeman S, Gordon S, Kelm S (1995) J Clin Invest 95: 635–43.

    PubMed  CAS  Google Scholar 

  17. Freeman SD, Kelm S, Barber EK, Crocker PR (1995) Blood 85:2005–12.

    PubMed  CAS  Google Scholar 

  18. Kelm S, Schauer R, Manuguerra J-C, Gross H-J, Crocker PR (1994) Glycoconj J 11: 576–85.

    Article  PubMed  CAS  Google Scholar 

  19. Nath D, van der Merwe PA, Kelm S, Crocker PR (1995) J Biol Chem 270: 26184–91.

    Article  PubMed  CAS  Google Scholar 

  20. Braesch-Andersen S, Stamenkovic I (1994) J Biol Chem 269: 11783–86.

    PubMed  CAS  Google Scholar 

  21. Engel P, Nojima Y, Rothstein D, Zhou L, Wilson GL, Kehrl JH, Tedder TF (1993) J Immunol 150: 4719–32.

    PubMed  CAS  Google Scholar 

  22. Engel P, Wagner N, Miller AS, Tedder TF (1995) J Exp Med 181: 1581–86.

    Article  PubMed  CAS  Google Scholar 

  23. Powell LD, Sgroi D, Sjoberg ER, Stamenkovic I, and Varki A (1993) J Biol Chem 268: 7019–27.

    PubMed  CAS  Google Scholar 

  24. Powell LD, Varki A (1994) J Biol Chem 269: 10628–36.

    PubMed  CAS  Google Scholar 

  25. Powell LD, Jain RK, Matta KL, Sabesan S, Varki A (1995) J. Biol Chem 270: 7523–32.

    Article  PubMed  CAS  Google Scholar 

  26. Sgroi D, Varki A, Braesch-Anderson S, Stamenkovic I (1993) J Biol Chem 268: 7011–18.

    PubMed  CAS  Google Scholar 

  27. Sjoberg E, Powell L, Klein A, Varki A (1994) J Cell Biol 126: 549–62.

    Article  PubMed  CAS  Google Scholar 

  28. Yang LJ, Zeller CB, Shaper NL, Kiso M, Hasegawa A, Shapiro RE, Schnaar RL (1996) Proc Natl Acad Sci USA 93: 814–18.

    Article  PubMed  CAS  Google Scholar 

  29. Collins BE, Yang LJ-S, Mukhopadhyay G, Filbin MT, Kiso M, Hasegawa A, Schnaar RL (1997) J Biol Chem 272: 1248–55.

    Article  PubMed  CAS  Google Scholar 

  30. Van der Merwe PA, Crocker PR, Vinson M, Barclay AN, Schauer R, Kelm S (1996) J Biol Chem 271: 9273–80.

    Article  PubMed  CAS  Google Scholar 

  31. Vinson M, van der Merwe PA, Kelm S, May A, Jones EY, Crocker PR (1996) J Biol Chem 271: 9267–72.

    Article  PubMed  CAS  Google Scholar 

  32. Law CL, Aruffo A, Chandran KA, Doty RT, Clark EA (1995) J Immunol 155: 3368–76.

    PubMed  CAS  Google Scholar 

  33. Holness CL, da Silva RP, Fawcett J, Gordon S, Simmons DL (1993) J Biol Chem 268: 9661–66.

    PubMed  CAS  Google Scholar 

  34. Crocker PR, Werb Z, Gordon S, Bainton DF (1990) Blood 76: 1131–38.

    PubMed  CAS  Google Scholar 

  35. Perry VH, Crocker PR, Gordon S (1992) J Cell Sci 101: 201–7.

    PubMed  Google Scholar 

  36. Kraal G (1992) Int Rev Cytol 132: 31–74.

    Article  PubMed  CAS  Google Scholar 

  37. Snook T (1964) Anat Rec 148: 149.

    Article  PubMed  CAS  Google Scholar 

  38. Damoiseaux JG, Huitinga I, Dopp EA, Dijkstra CD (1992) J Exp Med 176: 647–55.

    Article  PubMed  Google Scholar 

  39. Van den Berg TVd, van Die IV, Delavalette CR, Dopp AE, Smit LD, van der Meide PH, Tilders FJH, Crocker PR, Dijkstra CD (1996) J Immunol 157: 3130–38.

    PubMed  CAS  Google Scholar 

  40. Crocker PR, Hill M, Gordon S (1988) Immunology 65: 515–22.

    PubMed  CAS  Google Scholar 

  41. McWilliam AS, Tree P, Gordon S (1992) Proc Natl Acad Sci USA 89: 10522–26.

    Article  PubMed  CAS  Google Scholar 

  42. Doyle AG, Herbein G, Montaner LJ, Minty AJ, Caput D, Ferrara P, Gordon S (1994) Eur J Immunol 24: 1441–45.

    PubMed  CAS  Google Scholar 

  43. Hanasaki K, Powell LD, Varki A (1995) J Biol Chem 270: 7543–50.

    Article  PubMed  CAS  Google Scholar 

  44. Chappell T, Warren G (1989) J Cell Biol 109: 2693–702.

    Article  PubMed  CAS  Google Scholar 

  45. Simionescu N, Simionescu M, Palade GE (1981) J Cell Biol 90: 605–13.

    Article  PubMed  CAS  Google Scholar 

  46. Haldenby KA, Chappell DC, Winlove CP, Parker KH, Firth JA (1994) J Vasc Res 31: 2–9.

    PubMed  CAS  Google Scholar 

  47. Patel KD, Nollert MU, McEver RP (1995) J Cell Biol 131: 1893–902.

    Article  PubMed  CAS  Google Scholar 

  48. Crocker PR, Feizi T (1996) Curr Opin Struct Biol 6: 679–91.

    Article  PubMed  CAS  Google Scholar 

  49. Van den Berg TK, Breve JP, Damoiseaux JGMC, Dopp EA, Kelm S, Crocker PR, Dijkstra CD, Kraal G (1992) J Exp Med 176: 647–55.

    Article  PubMed  CAS  Google Scholar 

  50. Metcalf D, Lindeman GJ, Nicola NA (1995) Blood 85: 2364–70.

    PubMed  CAS  Google Scholar 

  51. Lord BI, Molineux G, Pojda Z, Souza LM, Mermod JJ, Dexter TM (1991) Blood 77: 2154–59.

    PubMed  CAS  Google Scholar 

  52. Lovas K, Knudsen E, Iversen PO, Benestad HB (1996) Eur J Haematol 56: 221–29.

    Article  PubMed  CAS  Google Scholar 

  53. Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, Andrian UHv, Arnaout MA, Mayadas TN (1996) Immunity 5: 653–66.

    Article  PubMed  Google Scholar 

  54. Liles WC, Kiener PA, Ledbetter JA, Aruffo A, Klebanoff SJ (1996) J Exp Med 184: 429–40.

    Article  PubMed  CAS  Google Scholar 

  55. Lagasse E, Weissman IL (1994) J Exp Med 179: 1047–52.

    Article  PubMed  CAS  Google Scholar 

  56. Cassidy LF, Lyles DS, Abramson JS (1989) J Immunol 142: 4401–06.

    PubMed  CAS  Google Scholar 

  57. Tsuji T, Nagata K, Koike J, Todoroki N, Irimura T (1994) J Leukoc Biol 56: 583–87.

    PubMed  CAS  Google Scholar 

  58. Wong CS, Gamble JR, Skinner MP, Lucas CM, Berndt MC, Vadas MA (1991) Proc Natl Acad Sci USA 88: 2397–401.

    Article  PubMed  CAS  Google Scholar 

  59. Abramson JS, Hudnor HR (1995) Blood 85: 1615–19.

    PubMed  CAS  Google Scholar 

  60. Trowbridge IS, Thomas ML (1994) Annu Rev Immunol 12: 85–116.

    Article  PubMed  CAS  Google Scholar 

  61. Ellies LG, Tao W, Fellinger W, Teh HS, Ziltener HJ (1996) Blood 88: 1725–32.

    PubMed  CAS  Google Scholar 

  62. Vachino G, Chang XJ, Veldman GM, Kumar R, Sako D, Fouser LA, Berndt MC, Cumming DA (1995) J Biol Chem 270: 21966–74.

    Article  PubMed  CAS  Google Scholar 

  63. Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U, Renz H, Hallmann R, Scheffold A, Radbruch A, Hamann A (1997) Nature 385: 81–83.

    Article  PubMed  CAS  Google Scholar 

  64. Dustin LB, Bullock ED, Hamada Y, Azuma T, Loh DY (1995) J Immunol 154: 4936–49.

    PubMed  CAS  Google Scholar 

  65. Bjorck P, Axelsson B, Paulie S (1991) Scand J Immunol 33: 211–18

    Article  PubMed  CAS  Google Scholar 

  66. Qiu L-B, Dickson H, Hajibagheri MAN, Crocker PR (1995) Blood 85: 1630–1640.

    PubMed  CAS  Google Scholar 

  67. Hakomori S (1989) Adv Canc Res 52: 257–331.

    Article  CAS  Google Scholar 

  68. Brockhausen I, Yang JM, Burchell J, Whitehouse C, Taylor-Papadimitriou J (1995) Eur J Biochem 233: 607–17.

    Article  PubMed  CAS  Google Scholar 

  69. Burchell J, Wang D, Taylor-Papadimitriou J (1984) Int J Cancer 34: 763–68.

    PubMed  CAS  Google Scholar 

  70. McGuckin MA, Devine PL, Ramm LE, Ward BG (1994) Tumour Biol 15: 33–44.

    Article  PubMed  CAS  Google Scholar 

  71. Schauer R (1982) Sialic acids: Chemistry, Metabolism and Function. New York: Springer Verlag.

    Google Scholar 

  72. Schenkman S, Eichinger D (1993) Parasitol Today 9: 218–22.

    Article  PubMed  CAS  Google Scholar 

  73. Engstler M, Schauer R (1993) Parasitol Today 9: 222–25.

    Article  PubMed  CAS  Google Scholar 

  74. Hammerschmidt S, Hilse R, van Putten JP, Gerardy Schahn R, Unkmeir A, Frosch M (1996) EMBO J 15: 192–98.

    PubMed  CAS  Google Scholar 

  75. van Putten JP, Grassme HU, Robertson BD, Schwan ET (1995) Prog Clin Biol Res 392: 49–58.

    PubMed  CAS  Google Scholar 

  76. Haft RF, Wessels MR, Mebane MF, Conaty N, Rubens CE (1996) Mol Microbiol 19: 555–63.

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. ICRF Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington Oxford, OX3 9DU, UK

    Paul R Crocker

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  1. Paul R Crocker
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  2. Adele Hartnell
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  3. James Munday
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  4. Deepa Nath
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Crocker, P.R., Hartnell, A., Munday, J. et al. The potential role of sialoadhesin as a macrophage recognition molecule in health and disease. Glycoconj J 14, 601–609 (1997). https://doi.org/10.1023/A:1018588526788

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