Abstract
The effect of Epithalon on melatonin and cortisol secretion in female rhesus monkeys of various ages was evaluated by enzyme immunoassay. Epithalon stimulated evening melatonin production and normalized circadian rhythms of cortisol production in old monkeys.
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REFERENCES
B. I. Kuznik, V. G. Morozov, and V. Kh. Khavinson, Cytomedines[in Russian], St. Petersburg (1998).
V. N. Anisimov, L. A. Bondarenko, and V. Kh. Khavinson, Ann. N. Y. Acad. Sci., 673, 53-57 (1992).
M. Ebadi, M. Samejima, and R. F. Pfeiffer, News Physiol. Sci., 8, 30 (1993).
L. H. Greenberg and B. Weiss, Science, 201, 61-63 (1978).
I. Haimov, P. Lavie, M. Laudon, et al., Sleep, 18, 598-603 (1995).
V. Kh. Khavinson, D. M. Ismailov, L. K. Obukhova, V. V. Malinin, et al., Mech. Ageing Dev., 120, 141-149 (2000).
B. Lemmer, T. Bruhl, K. Witte, et al., Eur. J. Endocrinol., 130, 472-477 (1994).
A. J. Lewy, T. A. Wehr, F. K. Goodwin, et al., Science, 210, 1267-1269 (1980).
W. Pierpaoli and W. Regelson, Proc. Natl. Acad. Sci. USA, 91, 787-791 (1994).
E. Tapp and M. Huxley, J. Pathol., 108, 137-144 (1972).
Y. Touitou, M. Fevre, M. Lagoguey, et al., J. Endocrinol., 91, 467-475 (1981).
Y. Touitou and E. Haus, Chronobiol. Int., 17, No. 3, 369-390 (2000).
R. J. Reiter and J. Robinson, Melatonin, New York (1995).
R. J. Reiter, Progr. Neurobiol., 56, 359-384 (1998).
R. J. Wurtman, J. Axelrod, and J. D. Barchas, J. Clin. Endocrinol. Metab., 24, 299-301 (1964).
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Goncharova, N.D., Khavinson, B.K. & Lapin, B.A. Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys. Bulletin of Experimental Biology and Medicine 131, 394–396 (2001). https://doi.org/10.1023/A:1017928925177
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DOI: https://doi.org/10.1023/A:1017928925177