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Compressed Donut-Shaped Tablets with Zero-Order Release Kinetics

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Abstract

Purpose. Simple uncoated compressed tablets with a central hole (donut-shape) are proposed to provide a constant drug release over a long period of time (>20 hrs). The effect of hole size and drug solubility on the release kinetics is investigated.

Methods. The donut-shaped polyethylene oxide (PEO, Mw = 4 × l06) tablets (600 mg and 12 mm diameter) are bored with a drill bit (3/32″, 7/64″, 1/8″, and 5/32″).

Results. The release of theophylline from the donut-shaped tablets is zero order (80 – 90% release) before rapidly decreasing. As the hole size is increased from 7/64″ to 5/32″, the release rate increases and the release time is shortened. However, the release of theophylline from the donut-shaped tablet with a hole size of 3/32″ follows the same anomalous release profile from a tablet without a hole. As drug solubility increases, the duration of linear drug release is shortened to 65 – 70% release followed by a severe tailing at the later stage of the release.

Conclusions. Donut-shaped PEO tablets with a hole provide zero-order release kinetics because the effect of the releasing surface area on the release kinetics is reduced.

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  1. School of Pharmacy, Temple University, 3307 N. Broad St., Philadelphia, Pennsylvania, 19140

    Cherng-ju Kim

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  1. Cherng-ju Kim
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Kim, Cj. Compressed Donut-Shaped Tablets with Zero-Order Release Kinetics. Pharm Res 12, 1045–1048 (1995). https://doi.org/10.1023/A:1016218716951

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