Abstract
Salbutamol laurate is a novel salt form of the well-known bronchodilator salbutamol (albuterol). Its polymorphism and inclusion in (2-hydroxypropyl)-β-cyclodextrinwere investigated by thermogravimetry, differential scanning calorimetry, infrared and powder X-ray diffraction techniques. Two polymorphic forms of the salt were identified. Conditions for inclusion complex formation between the salt and (2-hydroxypropyl)-β-cyclodextrin, namely prolonged co-grinding and kneading, were established by a combination of the above methods.
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References
The Merck Index, 12th edition, S. Budavari (Ed.), Merck & Co., Inc., Whitehouse Station, NJ, USA 1996, p. 213.
L. J. Penkler, South African Druggists International, personal communications.
N. Morin, A. Chilouet, J. Millet and J.-C. Rouland, J. Therm. Anal. Cal., 62 (2000) 187.
M. R. Caira, S. A. Bourne and E. Mvula, J. Therm. Anal. Cal., 56 (1999) 1329.
M. D. Veiga and M. Merino, Cyclodextrin: From Basic Research to Market, International Cyclodextrin Symposium, 10th, Ann Arbor, MI, USA, May 21-24, 2000 (Publisher: Wacker Biochem Corp., Adrian, MI, USA 2000, 653
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Caira, M.R., Dodds, D.R. & Nassimbeni, L.R. Polymorphism and Cyclodextrin Inclusion of Salbutamol Laurate. Journal of Thermal Analysis and Calorimetry 68, 647–655 (2002). https://doi.org/10.1023/A:1016064424699
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DOI: https://doi.org/10.1023/A:1016064424699