Abstract
A bilayer floating dosage unit is proposed to achieve local delivery of misoprostol, a prostaglandin E1 analogue, at the gastric mucosa level. The system is a capsule consisting of a floating layer maintaining the dosage unit buoyant upon the gastric content and a drug layer formulated to act as a sustained-delivery system. The differential design of the two layers allows the optimization of both floating capability and drug release profile. The layers are both composed of a hydrophilic matrix based upon hydroxypropylmethyl cellulose (HPMC). Parameters influencing the release profiles are described. The use of a large capsule increases the gastric residence time (GRT), as it impedes passage through the pylorus opening. γ-Scintigraphic studies were performed to visualize cohesion of the two layers in vivo and to determine GRT as a function of meal regimen. The average GRTs were 199 ± 69 min after a single meal (breakfast) and 618 ± 208 min after a succession of meals.
Similar content being viewed by others
REFERENCES
D. Duchêne, F. Touchard, and N. A. Peppas. Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev. Ind. Pharm. 14(2–3):283–318 (1988).
P. Buri, F. Puisieux, E. Doelker, and J. P. Benoit. Formes pharmaceutiques nouvelles. Technique et Documentation (Lavoisier), 1985, pp. 201–212.
P. R. Sheth and J. Tossounian. The hydrodynamically balanced system (HBS™): A novel drug delivery system for oral use. Drug Dev. Ind. Pharm. 10(2):313–339 (1984).
W. Erni and K. Held. The hydrodynamically balanced system: A novel principle of controlled drug release. Eur. Neuro. 27 (Suppl. l):21–27 (1987).
J. D. Cook, M. Carriaga, S. G. Kahn, W. Schalch, and B. S. Skikne. Gastric delivery system for iron supplementation. Lancet 335:1136–1139 (1990).
D. Khattar, A. Ahuja, and R. K. Khar. Hydrodynamically balanced systems as sustained release dosage forms for propranolol hydrochloride. Pharmazie 45:356–358 (1990).
J. Timmermans and A. J. Moës. How well do floating dosage forms float? Int. J. Pharm. 62:207–216 (1990).
J. Timmermans, B. Van Gansbeke, and A. J. Moës. Assessing by gamma scintigraphy the in vivo buoyancy of dosage forms having known size and floating force profiles in function of time. Proceedings of 5th International Conference on Pharmaceutical Technology (APGI Paris), 1989, Vol. 1, pp. 42–51.
J. G. Moore, P. E. Christian, J. A. Brown, C. Brophy, F. Datz, A. Taylor, and N. Alazraki. Influence of meal weight and caloric content on gastric emptying of meals in man. Digest. Dis. Sci. 29(6):513–519 (1984).
P. Mojaverian, R. K. Ferguson, P. H. Vlasses, M. L. Rocci, A. Oren, J. A. Fix, L. J. Caldwell, and C. Gardner. Estimation of gastric residence time of the Heidelberg capsule in humans: Effect of varying food composition. Gastroenterology 89(2):392–397 (1985).
P. Mojaverian, P. H. Vlasses, P. E. Kellner, and M. L. Rocci. Effects of gender, posture and age on gastric residence time of an indigestible solid: Pharmaceutical considerations. Pharm. Res. 5:639–644 (1988).
J. Timmermans and A. J. Moës. Unpublished data.
J. Timmermans and A. J. Moës. Measuring the resultant-weight of an immersed test material. Acta Pharm. Technol. 36(3):171–175 (1990).
G. D. Searle and Co. U.S. Patent pending 07,289,841 (1988).
G. D. Searle and Co. U.S. Patent 4060691 (1977).
G. D. Searle and Co. U.S. Patent pending (1990).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Oth, M., Franz, M., Timmermans, J. et al. The Bilayer Floating Capsule: A Stomach-Directed Drug Delivery System for Misoprostol. Pharm Res 9, 298–302 (1992). https://doi.org/10.1023/A:1015870314340
Issue Date:
DOI: https://doi.org/10.1023/A:1015870314340