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Are Reduction Potentials of Antifungal Agents Relevant to Activity?

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Abstract

Cyclic voltammetry data were obtained for several categories of fungicidal agents including quinones (akrobomycin, podosporin A), iminium ions and precursors (pyridazines, 15-azahomosterol, griseofulvin-4′-oxime), and metal derivatives of chelators (pyridine-2-aldehyde thiosemicarbazones). The reductions usually occurred in the range of −0.7 to +0.3 V. Reduction potentials provide information on the feasibility of electron transfer in vivo. Catalytic production of oxidative stress from redox cycling is a possible mode of action. Alternatively, there may be interference with normal electron transport chains.

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Authors and Affiliations

  1. Department of Chemistry, University of Wisconsin—Milwaukee, P.O. Box 413, Milwaukee, Wisconsin, 53201

    Peter Kovacic

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  1. Peter Kovacic
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  2. Patrick F. Kiser
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  3. Benjamin A. Feinberg
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Kovacic, P., Kiser, P.F. & Feinberg, B.A. Are Reduction Potentials of Antifungal Agents Relevant to Activity?. Pharm Res 7, 283–288 (1990). https://doi.org/10.1023/A:1015834431140

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