Skip to main content
SpringerLink
Log in

16α-Hydroxy-(–)-kauranoic Acid: A Selectively Cytotoxic Diterpene from Annona bullata

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

Abstract

Using brine shrimp lethality to direct fractionation, extracts of the bark of Annona bullata Rich. (Annonaceae) have yielded 16α-hydroxy-(–)-kauranoic acid as a bioactive plant constituent. This previously known diterpene showed significant (ED50 8.25 × 10−2 µg/ml) and selective cytotoxicity against A-549 (lung) cells in our panel of human tumor cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Y.-H. Hui, J. K. Rupprecht, Y.-M. Liu, J. E. Anderson, D. L. Smith, C.-J. Chang, and J. L. McLaughlin. J. Nat. Prod. 52:463–477 (1989)

    Google Scholar 

  2. J. L. McLaughlin and Y.-H. Hui. Chemotherapeutically Active Acetogenins, U.S. Patent, applied for April 11, 1989.

  3. B. N. Meyer, N. R. Ferrigni, J. E. Putnam, L. B. Jacobsen, D. E. Nichols, and J. L. McLaughlin. Planta Med. 45:31–34 (1982).

    Google Scholar 

  4. N. R. Ferrigni, J. E. Putnam, B. Anderson, L. B. Jacobsen, D. E. Nichols, D. S. Moore, and J. L. McLaughlin. J. Nat. Prod. 45:679–686 (1982).

    Google Scholar 

  5. G. Delgado, L. Alvarez, and A. R. De Vivax. Phytochemistry 24:2736–2738 (1985).

    Google Scholar 

  6. E. P. Serebryakov, N. S. Kobrina, A. V. Simolin, and V. F. Kucherov. Chem. Ind. 1770–1771 (1968).

  7. C. M. Hasan, T. M. Healey, and P. G. Waterman. Phytochemistry 21:2134–2135 (1982).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana, 47907

    Yu-hua Hui, Ching-jer Chang, David L. Smith & Jerry L. McLaughlin

Authors
  1. Yu-hua Hui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ching-jer Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David L. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jerry L. McLaughlin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hui, Yh., Chang, Cj., Smith, D.L. et al. 16α-Hydroxy-(–)-kauranoic Acid: A Selectively Cytotoxic Diterpene from Annona bullata . Pharm Res 7, 376–378 (1990). https://doi.org/10.1023/A:1015819422479

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1015819422479

Search

Navigation