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The role of regulated protein degradation in auxin response

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Abstract

Auxin-regulated gene expression is mediated by two families of transcription factors. The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. Mutations in components of SCFTIR1, a ubiquitin protein ligase (E3) result in stabilization of Aux/IAA proteins and decreased auxin response. Further, recent biochemical experiments indicate that the Aux/IAA proteins bind SCFTIR1 in an auxin-dependent manner.

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  1. Institute for Cellular and Molecular Biology, Section of Molecular Cell and Developmental Biology, University of Texas at Austin, Austin, TX, 7871, USA

    Sunethra Dharmasiri & Mark Estelle

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  1. Sunethra Dharmasiri
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  2. Mark Estelle
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Dharmasiri, S., Estelle, M. The role of regulated protein degradation in auxin response. Plant Mol Biol 49, 401–408 (2002). https://doi.org/10.1023/A:1015203013208

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  • DOI: https://doi.org/10.1023/A:1015203013208

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