Abstract
A cytogenetic study was conducted for the first time on human populations neighboring the Semipalatinsk nuclear test site (STS) and exposed to ionizing radiation for a long period of time. In populations with the extreme and maximum radiation risks, high frequencies of radiation-induced chromosomal markers, including acentric fragments (1.99 ± 0.10 per 100 cells), dicentrics (0.23 ± 0.01), ring chromosomes (0.38 ± 0.14), and stable chromosomal aberrations (1.17 ± 0.02), were found. These frequencies significantly exceeded those in control populations. The spectrum of chromosomal aberrations and the frequencies of the aberrations of different types in persons living in the areas with the highest radionuclide contamination confirmed the mutagenic effect of radiation on chromosomes in the human populations studied.
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REFERENCES
Kuleshov, N.P., Frequency and Fate of Chromosomal Anomalies in Humans, Abstract of Doctoral Dissertation, Moscow, 1979.
Dubinin, N.P. and Soyfer, V.N., Chromosomal Breakage and Complete Genic Mutation Production in Molecular Terms, Mutat. Res., 1969, vol. 18, pp. 353-365.
Ohtaki, K., G-Banding Analysis of Radiation-Induced Chromosome Damage in Lymphocytes of Hiroshima A-Bomb Survivors, Jpn. J. Hum. Genet., 1992, vol. 37, pp. 245-262.
Vogel, F. and Motulsky, A.G., Human Genetics, Berlin: Springer-Verlag, 1986, 2nd ed.
Bostok, L. and Samner, E., Khromosoma eukarioticheskoi kletki (Eukaryotic Chromosome), Moscow: Mir, 1981.
Cryer, D.R., Goltwalte, C.D., and Zinker, S., Studies on Nuclear and Mitochondrial DNAs of Saccharomyces cerevisiae, Cold Spring Harbor Symp. Chrom. Struct. Funct., N.Y., 1974, vol. 37, pp. 17-29.
Rukovodstvo po izucheniyu geneticheskikh effektov v populyatsiyakh cheloveka (Studies on Genetic Effects in Human Populations: A Manual), WHO, 1989.
Leonard, R.C., Bender, M.A., Puston, R.J., et al., The Effect of Age on Cytogenetic Measurements in a Large Population Sample, Environ. Mol. Mutagen., 1988, vol. 11, no. 11, p. 59.
Lloyd, D.C., Edwards, A.A., Leonard, R., et al., Frequencies of Chromosomal Aberrations Induced in Human Blood Lymphocytes by Low Doses of X-Rays, Int. J. Radiat. Biol., 1988, vol. 53, no. 1, pp. 49-55.
Bayrchinger, M., Quantification of Low-Level Radiation Exposure by Conventional Chromosome Aberration Analysis, Mutat. Res., 1995, vol. 339, pp. 177-189.
Doida, J., Sugahara, T., and Horikawa, M., Studies of Some Radiation-Induced Chromosome Aberrations in Man, Radiat. Res., 1965, vol. 26, no. 1, p. 697.
Leonard, R.C., Human Radiation Effect: An Overview, Health Physics, 1992, vol. 23, pp. 64-67.
Bloom, A.D., et al., Cytogenetic Investigations of Survivors of the Atomic Bombing of Hiroshima and Nagasaki, Lancet, 1966, no. 2, p. 672.
Wolf, S. and Bodycote, J., The Induction of Chromatid Deletions Associated with Breakage and Reunion Hypothesis, Mutat. Res., 1975, vol. 29, p. 85.
Hubner, K., Littlefield, G., and Du Frain, R., Experience in the Practical Application of the Biological Indicators, München: MMV Med. Verlag, 1986, no. 2, pp. 17-34.
Stone, D.H., The Glasgow Register of Congenital Anomalies, 1972-1988: A Critical Review, J. Inherit. Metab. Dis., 1989, vol. 12, pp. 4-12.
Evans, H.J., Leukemia and Radiation, Nature, 1990, vol. 345, pp. 16-17.
Goodhead, D.T., Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA, Int. Rad. Biol., 1994, vol. 137, pp. 275-289.
Zoetelief, J., Broerse, J.J., and Barensen, G.W., Radiation Carcinogenesis and DNA Alterations, New York: Plenum, 1986, pp. 195-207.
Abil'dinova, G.Zh., Study on Stable and Unstable Aberrations Induced by Exposure to Low-Dose Ionizing. Radiation, Abstract of Cand. Sci. (Med.) Dissertatio, Moscow, 1993.
Raketskaya, V.V., Study of the Informativeness of Cyto-genetic Methods in Diagnostics of Radiation Exposure, Cand. Sci. (Biol.) Dissertatio, Moscow, 1994.
Stephan, G. and Oestreicher, U., An Increased Frequency of Chromosome Aberrations in Persons Present in the Vicinity of Chernobyl during and after the Reactor Accident: Is This Effect Caused by Radiation Exposure?, Mutat. Res., 1989, vol. 223, pp. 7-12.
Bochkov, N.P., Katosova, L.D., Novikov, P.V., et al., Cytogenetic Examination of Children Living in Houses with a Varying Extent of Radioactive Pollution, Med. Radiol. Radiats. Bezopasn., 1994, vol. 39, no. 5, pp. 35-38.
Charles, E. and Land, Ph.D., Studies of Cancer and Radiation Dose among Atomic Bomb Survivors, J. Am. Med. Acad., 1995, vol. 274, no. 5, pp. 402-407.
Filyushkin, I.V., Concept of a Life-Time Dose of 350 MSv, Health Physics, 1991, vol. 61, pp. 401-404.
Joner, M.C., Robson, T., Singh, B., et al., Role of DNA Repair in Low-Dose X-Ray-Induced Radioresistance, Radiation and Research, 1895-1995: Congress Proceedings, Wurzburg, 1995, vol. 1, p. 312.
Low-Dose Radiation: Biological Bases of Risk Assessment, Baverstock, K.F. and Staner, J.W., Eds., London: Taylor and Francic, 1989.
Ludwig, E., Radiation Effects Induced by Low Doses in Complex Tissue and Their Relation to Cellular Responses, J. Am. Med. Acad., 1996 (personal communication).
Luchnik, N.V. and Sevankaev, A.V., Radiation-Induced Chromosomal Aberrations in Human Lymphocytes: I. Dependence on the Dose of γ-Rays and an Anomaly at Low Doses, Mutat. Res., 1976, vol. 36, pp. 363-374.
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Svyatova, G.S., Abil'dinova, G.Z. & Berezina, G.M. Results of a Cytogenetic Study of Populations with Different Radiation Risks in the Semipalatinsk Region. Russian Journal of Genetics 38, 294–299 (2002). https://doi.org/10.1023/A:1014858919263
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DOI: https://doi.org/10.1023/A:1014858919263