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Synthesis of a coumarin based fluorescent amino acid

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Abstract

L-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid (L-Adp), as a non-proteinogenic fluorescent amino acid has been synthesized by a highly stereoselective routine (>99.5%). This fluorescent amino acid, as fluorophore-quencher pair, may be used to study peptide assays. For enantiomeric excess determination, the racemic D-Adp (D-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid) has also been synthesized.

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Authors and Affiliations

  1. Center for Supramolecular Science and Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, 33124, U.S.A

    Guodong Sui, Péter Kele, Jhony Orbulescu & Qun Huo

  2. Center for Supramolecular Science and Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, 33124, U.S.A.

    Roger M. Leblanc

Authors
  1. Guodong Sui
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  2. Péter Kele
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  3. Jhony Orbulescu
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  4. Qun Huo
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  5. Roger M. Leblanc
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Sui, G., Kele, P., Orbulescu, J. et al. Synthesis of a coumarin based fluorescent amino acid. Letters in Peptide Science 8, 47–51 (2001). https://doi.org/10.1023/A:1014280017576

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  • DOI: https://doi.org/10.1023/A:1014280017576

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