Chitosan-based hydrogels: Synthesis and characterization

Abstract

Chitosan (CHI) is a polysaccharide of β-1,4-linked 2-amino-2-deoxy-D-glucopyranose derived by N-deacetylation of chitin in aqueous alkaline medium. The shells of crustaceans such as crabs, shrimp, and lobster are the current source of chitosan. It is known to be non-toxic, odourless, biocompatible in animal tissues and enzymatically biodegradable. For these reasons much research interest has been paid to its biomedical, ecological, and industrial applications over the past decade. However, its rigid crystalline structure, poor solubility in organic solvents and poor processability have limited its use. To broadening its range of applications, a growth research effort has been devoted to explore ways of modifying Chitosan. Here it has been reported on the synthesis of new hydrogels, obtained by self-curing chitosan with acrylic acid (AA) and methyl acrylate (MA). The hydrogels were characterized by FTIR, swelling and rheological analysis. The results of this study showed that the swelling and mechanical properties of chitosan are highly improved by the presence of poly acrylate. The swelling degree of these materials does not depend upon the ratio MA/AA. It is possible to improve and modulate the mechanical properties of the hydrogels by changing the relative MA/AA ratio.

© 2001 Kluwer Academic Publishers