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Comparison of Generic Hydrochlorothiazide Formulations by Means of TG and DSC Coupled to a Photovisual System

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Abstract

The compatibilities and stabilities of some binary mixtures and generic hydrochlorothiazide formulations were studied by using TG, DSC and a DSC-photovisual system. The kinetic parameters were determined via the Arrhenius equations. Tablet B presented higher compatibility and thermal stability than those of tablets A and C. The photovisual system demonstrated that the decomposition of tablet A occurs before the melting point, due to the Maillard reaction between the hydrochlorothiazide and lactose present in the formulation. The behaviour and rate constants of binary mixtures suggest that lactose can be substituted for microcrystalline cellulose, MC(101), in tablet A. The DSC and TG data revealed different characteristics of compatibility and stability in generic formulations from different manufacturers.

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References

  1. R. O. Macêdo, T. G. Do Nascimento, C. S. F. S. Aragão and A. P. Barreto Gomes, J. Therm. Anal. Cal., 59 (2000) 657.

    Article  Google Scholar 

  2. R. O. Macêdo, A. G. De Souza and A. M. C. Macêdo, J. Therm. Anal. Cal., 49 (1997) 937.

    Google Scholar 

  3. R. O. Macêdo, C. S. F. S. Aragão, T. G. do Nascimento and A. M. C. Macêdo, J. Therm. Anal. Cal., 56 (1999) 1323.

    Article  Google Scholar 

  4. D. J. Giron and M. Drachi, J. Thermal Anal., 49 (1997) 913.

    Article  CAS  Google Scholar 

  5. D. J. Giron, Pharm. Biomed. Anal., 4 (1986) 755.

    Article  CAS  Google Scholar 

  6. C. J. Keattch and D. Dollimore, Introduction to Thermogravimetry, 2nd ed., Heyden 1975.

  7. S.-Y. P. King, M. S. Kung and H. L. Fung, J. Pharm. Sciences, 73 (1994) 657.

    Google Scholar 

  8. The Merck Index, 12th ed., 1996.

  9. United States Pharmacopeal, XXIII Ed., National Formulary, 18, 1995.

  10. J. L. Ford and P. Timmins, Pharmaceutical Thermal Analysis: Techniques and Applications, Ellis Horwood, England 1989.

    Google Scholar 

  11. D. J. Giron, Thermochim. Acta, 248 (1995) 1.

    Article  CAS  Google Scholar 

  12. D. D. Wirth and S. M. Gregg, J. Pharm. Sciences, 87 (1998) 31.

    Article  CAS  Google Scholar 

  13. P. A. Harmon, W. Yin, W. E. Bowen, R. J. Tyrell and R. A. Reed, J. Pharm. Sciences, 89 (2000) 920.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Campus I, João Pessoa, PB, 58059-900, Brazil

    R. O. Macêdo, T. G. do Nascimento & J. W. E. Veras

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  1. R. O. Macêdo
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  2. T. G. do Nascimento
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  3. J. W. E. Veras
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Macêdo, R.O., do Nascimento, T.G. & Veras, J.W.E. Comparison of Generic Hydrochlorothiazide Formulations by Means of TG and DSC Coupled to a Photovisual System. Journal of Thermal Analysis and Calorimetry 64, 757–763 (2001). https://doi.org/10.1023/A:1011504730402

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  • DOI: https://doi.org/10.1023/A:1011504730402

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