Abstract
A `biocompatible' safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.
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Orain, D., Bradley, M. A safety-catch linker for amine release under biologically compatible conditions. Mol Divers 5, 25–34 (2000). https://doi.org/10.1023/A:1011355300910
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DOI: https://doi.org/10.1023/A:1011355300910