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Acute leukemia in electrical workers: a New Zealand case–control study

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Abstract

Objectives: To assess the risks for adult-onset acute leukemia associated with electrical employment in New Zealand.

Methods: The occupational and environmental exposures histories of 110 incident leukemia cases and 199 general population controls were compared. The cases were recruited through referrals to treatment centers in New Zealand between 1989 and 1991. For subjects classified as having worked in one or more of the “electrical occupations,” the degree of exposures to extremely low frequency electromagnetic fields (ELF-EMFs) was assessed in detail using a job-exposure matrix.

Results: An odds ratio of 1.9 (95% Cl 1.0–3.8) was found for subjects who had ever worked in an electrical occupation. Significantly increased risks for leukemia are seen amongst welders/flame cutters (OR = 2.8 (95% Cl 1.2–6.8)) and telephone line workers (OR = 5.81 (95% Cl 1.2–27.8)). The excess leukemia risk appeared to be confined to acute non-lymphocytic leukemia (OR = 2.31 (95% Cl 1.2–4.6)), in comparison to acute lymphoblastic leukemia (OR = 0.9 (95% Cl 0.3–2.9)) but for the latter category the numbers were very small. A dose–response effect was also found, with acute leukemia risk rising with increasing occupational magnetic field exposure, based on both current and historical occupational field exposure estimates.

Conclusions: The findings of the current study indicate a significantly elevated risk of acute leukemia for electrical workers overall, and for the specific occupational categories of welders/flame cutters and telephone line workers. A dose–response effect was also found, indicating that acute leukemia risk was related to historical and current magnetic field exposures in an occupational context.

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References

  1. Pearce NE, Sheppard RA, Howard JK, Fraser J, Lilley BM (1986) Leukemia among New Zealand agricultural workers. A cancer registry-based study. Am J Epidemiol 124: 402–409.

    Google Scholar 

  2. Reif J, Pearce N, Fraser J (1989) Cancer risks in New Zealand farmers. Int J Epidemiol 18: 768–774.

    Google Scholar 

  3. Blair A, Zahm SH Pearce NE, Heineman EF, Fraumeni JF Jr (1992) Clues to cancer etiology from studies of farmers. Scand J Work Environ Health 18: 209–215.

    Google Scholar 

  4. Kristensen P, Andersen A, Irgens LM, Laake P, Bye AS (1996) Incidence and risk factors of cancer among men and women in Norwegian agriculture. Scand J Work Environ Health 22: 14–26.

    Google Scholar 

  5. Reif J, Pearce N, Fraser J (1989) Cancer risks among New Zealand meat workers. Scand J Work Environ Health 15: 24–29.

    Google Scholar 

  6. Guberan E, Usel M, Raymond L, Fioretta G (1993) Mortality and incidence of cancer among a cohort of self employed butchers from Geneva and their wives. Br J Ind Med 50: 1008–1016.

    Google Scholar 

  7. Dubrow R, Wegman DH (1984) Cancer and occupation in Massachusetts: a death certificate study. Am J Ind Med 6: 207–230.

    Google Scholar 

  8. Morton W, Marjanovic D (1984) Leukemia incidence by occupation in the Portland-Vancouver metropolitan area. Am J Ind Med 6: 185–205.

    Google Scholar 

  9. Linet MS, Malker HS, McLaughlin JK et al. (1988) Leukemias and occupation in Sweden: a registry-based analysis. Am J Ind Med 14: 319–330.

    Google Scholar 

  10. Loomis DP, Savitz DA (1991) Occupation and Leukemia mortality among men in 16 states: 1985–1987. Am J Ind Med 19: 509–521.

    Google Scholar 

  11. Savitz DA, Calle EE (1987) Leukemia and occupational exposure to electromagnetic fields: review of epidemiologic surveys. J Occup Med 29: 47–51.

    Google Scholar 

  12. Ahlbom A (1988) A review of the epidemiologic literature on magnetic fields and cancer. Scand J Work Environ Health 14: 337–343.

    Google Scholar 

  13. Kheifets LI, Afifi, AA, Buffer PA, et al. (1997) Occupational electric and magnetic field exposure and leukemia. J Occup Med 39: 1074–1091.

    Google Scholar 

  14. Bowman JD, Sobel E, London SJ, et al. (1992) Electric and magnetic field exposure, chemical exposure and leukemia risk in “electrical occupations.” Electric Power Research Institute, Palo Alto, CA.

    Google Scholar 

  15. Bethwaite PB, McLean DJ, Kennedy J, Pearce NE (2000) Adult-onset acute leukemia and employment in the meant industry: a New Zealand case-control study. Cancer Causes Control (In press.)

  16. Health Statistical Services (1992) Cancer Registrations and Deaths, 1988 & 1989. Wellington: New Zealand Department of Health.

    Google Scholar 

  17. Bennett JM, Catovsky D, Daniel MT, et al. (1976) Proposal for the classification of the acute leukemias. French-American-British (FAB) Co-operative Group. Br J Haematol 33: 451–458.

    Google Scholar 

  18. Smith AH, Fisher DO, Pearce NE, et al. (1982) Do agricultural chemicals cause soft tissue sarcoma? Initial findings of a case-control study in New Zealand. Commun Health Stud 6: 114–119.

    Google Scholar 

  19. Pearce N, Smith AH, Howard JK, et al. (1986) Non-Hodgkin's lymphoma and exposure to phenoxyherbicides, chlorophenols, fencing work and meat works employment: a case-control study. Br J Ind Med 43: 75–83.

    Google Scholar 

  20. Department of Statistics (1980) New Zealand Standard Classification of Occupations. Wellington: NZ Department of Statistics.

    Google Scholar 

  21. International Labour Office (1968) International Standard Classification of Occupations. Geneva: ILO.

    Google Scholar 

  22. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719–748.

    Google Scholar 

  23. Miettinen OS (1976) Estimability and estimation in case-referent studies. Am J Epidemiol 103: 226–235.

    Google Scholar 

  24. Milham S Jr (1982) Mortality from leukemia in workers exposed to electrical and magnetic fields. N Engl J Med 307: 249.

    Google Scholar 

  25. Savitz DA, Calle EE (1987) Leukemia and occupational exposure to electromagnetic fields: review of epidemiologic surveys. J Occup Med 29: 47–51.

    Google Scholar 

  26. Stern RM (1987) Cancer incidence among welders: possible effects of exposure to extremely low frequency electromagnetic radiation (ELF) and to welding fumes. Environ Health Perspect 76: 221–229.

    Google Scholar 

  27. Morton W, Marjanovic D. Leukemia incidence by occupation in the Portland-Vancouver metropolitan area. Am J Ind Med 6: 185–205.

  28. Tornqvist S, Knave B, Ahlbom A, Persson T (1991) Incidence of Leukemia and brain tumours in some “electrical occupations.” Br J Ind Med 48: 597–603.

    Google Scholar 

  29. Richardson S, Zittoun R, Bastuji-Garin S, et al. (1992) Occupational risk factors for acute leukemia: a case-control study. Int J Epidemiol 21: 1063–1073.

    Google Scholar 

  30. Ciccone G, Mirabelli D, Levis A, et al. (1993) Myeloid leukemias and myelodysplastic syndromes: chemical exposure, histologic subtype and cytogenetics in a case-control study. Cancer Genet Cytogenet 68: 135–139.

    Google Scholar 

  31. Stern FB, Waxweiler RA, Beaumont JJ, et al. (1986) A case control study of leukemia at a naval nuclear shipyard. Am J Epidemiol 123: 980–992.

    Google Scholar 

  32. London SJ, Bowman JD, Sobel E, et al. (1994) Exposure to magnetic fields among electrical workers in relation to leukemia risk in Los Angeles County. Am J Ind Med 26: 47–60.

    Google Scholar 

  33. Floderus B, Persson T, Stenlund C, et al. (1993) Occupational exposure to electromagnetic fields in relation to leukemia and brain tumors: a case-control study in Sweden. Cancer Causes Control 4: 465–476.

    Google Scholar 

  34. Matanoski GM, Elliott EA, Breysse PN, Lynberg MC (1993) Leukemia in telephone lineman. Am J Epidemiol 137: 609–619.

    Google Scholar 

  35. Theriault G, Goldberg M, Miller AB, Armstrong B, et al. (1994) Cancer risks associated with occupational exposure to magnetic fields among electric utility workers in Ontario & Quebec, Canada, and France: 1970–89. Am J Epidemiol 139: 550–572.

    Google Scholar 

  36. Kromhout H, Loomis DP, Mihlan GJ, et al. (1995) Assessment and grouping of occupational magnetic field exposure in five utility companies. Scand J Work Environ Health 21: 43–50.

    Google Scholar 

  37. Floderus B (1996) Is job title an adequate surrogate to measure magnetic field exposure? Epidemiology 7: 115–116.

    Google Scholar 

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Authors and Affiliations

  1. Medical Laboratory Wellington, 89 Courtenay Place, Wellington, New Zealand

    Peter Bethwaite

  2. Department of Public Health, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand

    Peter Bethwaite, Angus Cook, Josephine Kennedy & Neil Pearce

  3. Centre for Public Health Research, Massey University Wellington Campus, Private Box 756, Wellington, New Zealand

    Neil Pearce

Authors
  1. Peter Bethwaite
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  2. Angus Cook
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  3. Josephine Kennedy
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  4. Neil Pearce
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Bethwaite, P., Cook, A., Kennedy, J. et al. Acute leukemia in electrical workers: a New Zealand case–control study. Cancer Causes Control 12, 683–689 (2001). https://doi.org/10.1023/A:1011297803849

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