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Solubility Study of Nimodipine Inclusion Complexation with α- and β-Cyclodextrin and some Substituted Cyclodextrins

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Abstract

The solubility of nimodipine was measured in aqueous solutions of the following cyclodextrins: α-cyclodextrin (α-CD), hydroxypropyl-α-CD (HP-α-CD), β-cyclodextrin (β-CD), random substituted methyl-β-CD (M-β-CD), three hydroxypropyl-β-CDs (HP-β-CD) with mutually different average degree of substitution, and hydroxypropyl-γ-cyclodextrin (HP-γ-CD). From the determined linear solubility diagrams the values of the binding constant K11 of the inclusion complexes of nimodipine with the respective CDs were evaluated. The β-CDs efficiently solubilized sparingly soluble nimodipine, the highest value of K11 was found for M-β-CD (1680 M-1), followed by β-CD (550 M-1) and HP-β-CDs, where the higher degree of substitution lowered K11. Only slight solubilization of nimodipine was observed in the solutions of the α-CDs and HP-γ-CD.

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Authors and Affiliations

  1. Faculty of Pharmacy, Comenius University, Odbojárov 10, SK-83232, Bratislava, Slovak Republic

    František Kopecký, Božena Kopecká & Pavol Kaclík

Authors
  1. František Kopecký
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  2. Božena Kopecká
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  3. Pavol Kaclík
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Kopecký, F., Kopecká, B. & Kaclík, P. Solubility Study of Nimodipine Inclusion Complexation with α- and β-Cyclodextrin and some Substituted Cyclodextrins. Journal of Inclusion Phenomena 39, 215–217 (2001). https://doi.org/10.1023/A:1011155208944

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  • DOI: https://doi.org/10.1023/A:1011155208944

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