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Tissue Engineering at the Micro-Scale

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Abstract

The possibility to replace damaged or diseased organs with artificial tissues engineered from a combination of living cells and biocompatible scaffolds is becoming a reality through multi-disciplinary efforts. A number of critical components within this effort are being facilitated by microfabrication and MEMS approaches, including research tools to elucidate mechanisms which control cellular behavior as well as development of methods to manufacture cellular scaffolds at ever higher resolutions. This article reviews recent advances in tissue engineering that have been facilitated by interaction with the microfabrication community. We highlight the potential opportunities for microfabrication to make to the development of mainstream medical therapies for tissue replacement.

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Abbreviations

CAD:

computer-aided design

ECM:

extracellular matrix

PMMA:

polymethyl methacrylate

PDMS:

polydimethyl siloxane

PLA:

polylactic acid

PLGA:

polylactic (co-glycolic) acid

SFF:

solid freeform fabrication

TEMP:

tissue engineered medical product

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  1. Department of Bioengineering, University of California, San Diego, La Jolla, CA

    Sangeeta N. Bhatia

  2. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD

    Christopher S. Chen

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Bhatia, S.N., Chen, C.S. Tissue Engineering at the Micro-Scale. Biomedical Microdevices 2, 131–144 (1999). https://doi.org/10.1023/A:1009949704750

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