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Estimation of Gibbs energy changes of central metabolism reactions

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Biotechnology Techniques

Abstract

Changes in Gibbs energies of metabolic reactions of glycolysis and Krebs cycle have been calculated from literature data including ΔG, pK values, and complex formation constants values. Neutral, charged species and Mg-complexes are included in the data base. Results show that most of the reactions investigated proceed near thermodynamic equilibrium conditions whereas the reactions out of equilibrium are related to the metabolic regulation and seem associated with cyclic sequences or with parallel pathways. Examples of fructose 6-phosphate/fructose 1,6-diphosphate cycle and phosphotranferase system and hexokinase are presented.

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Authors and Affiliations

  1. Laboratoire de Génie Chimique Biologique, 24, avenue des Landais, 63177, Aubière cedex, France

    C.B. Ould-Moulaye, C.G. Dussap & J.B. Gros

Authors
  1. C.B. Ould-Moulaye
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  2. C.G. Dussap
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  3. J.B. Gros
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Ould-Moulaye, C., Dussap, C. & Gros, J. Estimation of Gibbs energy changes of central metabolism reactions. Biotechnology Techniques 13, 187–193 (1999). https://doi.org/10.1023/A:1008962302957

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  • DOI: https://doi.org/10.1023/A:1008962302957

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