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Interaction of Hydroxy Acids with β-Cyclodextrin

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Abstract

The solubility of β-cyclodextrin (β-CD) was studied in aqueous solutions of various organic acids. The hydroxy acids, especially citric and tartaric acid were found to increase the solubility of β-CD, while some other carboxylic acids reduced it. From solubility data the apparent complex association constants were calculated.

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Authors and Affiliations

  1. Cyclolab Research and Development Laboratory Ltd., Budapest, 1117, Dombóvári út 5-7, Hungary

    E. Fenyvesi, M. Vikmon, J. Szeman & J. Szejtli

  2. Chiesi Farmaceutici S.p.A., Parma, Via Palermo 26/A, Italy

    E. Redenti, M. Delcanale & P. Ventura

Authors
  1. E. Fenyvesi
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  2. M. Vikmon
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  3. J. Szeman
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  4. E. Redenti
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  5. M. Delcanale
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  6. P. Ventura
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  7. J. Szejtli
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Fenyvesi, E., Vikmon, M., Szeman, J. et al. Interaction of Hydroxy Acids with β-Cyclodextrin. Journal of Inclusion Phenomena 33, 339–344 (1999). https://doi.org/10.1023/A:1008094702632

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  • DOI: https://doi.org/10.1023/A:1008094702632

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