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Targeting DNA methyltransferase in cancer

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Abstract

DNA methyltransferase is an enzyme responsible for generating and maintaining DNA methylation patterns. DNA methylation patterns control different genome functions, thus they are an important component of the epigenetic information. It has been recently postulated that DNA methyltransferase plays an important role in oncogenesis and that it is a candidate target for anticancer therapy. This commentary discusses the possible mechanisms through which DNA methyltransferase participates in oncogenesis and the rationale for targeting it in cancer.

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  1. Department of Pharmacology, McGill University, Montreal, PQ, Canada

    Moshe Szyf

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Szyf, M. Targeting DNA methyltransferase in cancer. Cancer Metastasis Rev 17, 219–231 (1998). https://doi.org/10.1023/A:1006023023787

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