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Regulation of Keratinocyte Growth Factor (KGF) and KGF Receptor mRNAs by Nutrient Intake and KGF Administration in Rat Intestine

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Abstract

The aim of this study was to investigate the regulation of keratinocyte growth factor (KGF) and KGF receptor mRNAs by diet and KGF treatment in rat intestine. Fasting for three days up-regulated KGF and KGF receptor mRNA levels in ileum and increased KGF receptor mRNA expression in colon. KGF and KGF receptor mRNA levels returned toward control values with ad libitum refeeding but remained elevated when refeeding was limited to 25% of ad libitum intake. KGF treatment during nutrient repletion did not alter intestinal KGF mRNA levels but increased KGF receptor mRNA abundance in ileum and colon. We conclude that the increase in KGF and KGF receptor mRNAs induced by malnutrition may be an adaptive response to attenuate gut mucosal atrophy in this setting. The gut-trophic effects of KGF treatment may be mediated, in part, by up-regulation of the KGF receptor mRNA in small bowel and colon.

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Authors and Affiliations

  1. Departments of Medicine, Emory University School of Medicine, Georgia

    Concepción F. Estívariz, Li H. Gu, Sheila Scully, Alana Eli, Carolyn R. Jonas, Catherine L. Farrell & Thomas R. Ziegler

  2. Department of Pathology, Amgen Inc., Thousand Oaks, California, 91320-1789

    Concepción F. Estívariz, Li H. Gu, Sheila Scully, Alana Eli, Carolyn R. Jonas, Catherine L. Farrell & Thomas R. Ziegler

  3. Nutrition and Health Sciences Program, Emory University, Atlanta, Georgia, 30322

    Concepción F. Estívariz, Li H. Gu, Sheila Scully, Alana Eli, Carolyn R. Jonas, Catherine L. Farrell & Thomas R. Ziegler

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  1. Concepción F. Estívariz
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Estívariz, C.F., Gu, L.H., Scully, S. et al. Regulation of Keratinocyte Growth Factor (KGF) and KGF Receptor mRNAs by Nutrient Intake and KGF Administration in Rat Intestine. Dig Dis Sci 45, 736–743 (2000). https://doi.org/10.1023/A:1005447827579

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