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Synthesis of Polysubstituted 1,4-Diazacycloheptan-5-ones. 1. Synthesis and Conformational Investigation of Polysubstituted 4-Piperidones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A series of tri- and tetrasubstituted 4-piperidones and their bicyclic analogs has been synthesized. It was established by 1H NMR spectroscopy that all the piperidones obtained have the chair conformation in solution with equatorially disposed substituents.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, Moscow, 119899, Russia

    S. Z. Vatsadze, Yu. V. Krainova, M. A. Kovalkina & N. V. Zyk

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  1. S. Z. Vatsadze
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  2. Yu. V. Krainova
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  3. M. A. Kovalkina
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  4. N. V. Zyk
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Vatsadze, S.Z., Krainova, Y.V., Kovalkina, M.A. et al. Synthesis of Polysubstituted 1,4-Diazacycloheptan-5-ones. 1. Synthesis and Conformational Investigation of Polysubstituted 4-Piperidones. Chemistry of Heterocyclic Compounds 36, 1185–1191 (2000). https://doi.org/10.1023/A:1002820816850

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  • DOI: https://doi.org/10.1023/A:1002820816850

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