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Analysis of Genetic Diversity of North Eurasian Populations Using Autosomal Microsatellite Loci

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Abstract

The paper presents the results of analysis of the gene pools of several North Eurasian ethnic groups (Buryats, Evenks, Altaians, Russians, Kyrgyzes, Tuvinians, Tatars, and Ukrainians) examined using a panel of autosomal microsatellite markers (D4S397,D5S393, D7S640, D8S514, D9S161, D10S197, D11S1358, D12S364 and D13S173) mapped on different chromosomes and represented by the (CA) n dinucleotide repeats. In the group of populations examined the proportion of genetic variability at microsatellite loci explained by interpopulation differences was about 2.5%, while genetic differences between the individuals within a population accounted for 97.5% of this variability. Analysis of genetic relationships among the populations revealed substantial differences between the populations belonging to the Indo-European and Altaic linguistic families in gene diversity at microsatellite loci.

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References

  1. Weber, J. and May, P., Abundant Class of Human DNA Polymorphism Which Can Be Typed Using the Polymerase Chain Reaction, Am. J. Hum. Genet., 1989, vol. 44, pp. 388–396.

    Google Scholar 

  2. Weber, J. and Wong, C., Mutation of Human Short Tandem Repeats, Genetics, 1993, vol. 2, pp. 1123–1128.

    Google Scholar 

  3. Brinkmann, B., Klintschar, M., Neuhuber, F., et al., Mutation Rate in Human Microsatellites, Am. J. Hum. Genet., 1998, vol. 62, pp. 1408–1415.

    Google Scholar 

  4. Slatkin, M., A Measure of Population Subdivision Based on Microsatellite Frequencies, Genetics, 1995, vol. 139, pp. 457–462.

    Google Scholar 

  5. Kimpton, C., Gill, P., Walton, A., et al., Automated DNA Profiling Employing Multiplex Amplification of Short Tandem Repeat Loci, PCR Methods Appl., 1993, vol. 3, pp. 13–22.

    Google Scholar 

  6. Li Jin, Underhill, P., Buoncristiani, M., et al., Defining Microsatellite Alleles by Genotyping Global Indigenous Human Populations and Non-Human Primates, J. Forensic Sci., 1996, vol. 42, pp. 496–499.

    Google Scholar 

  7. Hearn, C.M., Ghosh, S., and Todd, J.A., Microsatellites for Linkage Analysis of Genetic Traits, Trends Genet., 1992, vol. 8, pp. 288–294.

    Google Scholar 

  8. Dib, C., Faure, S., Fizames, C., et al., A Comprehensive Genetic Map of the Human Genome Based on 5254 Microsatellites, Nature 1996, vol. 380, pp. 152–154.

    Google Scholar 

  9. Deka, R., Shriver, M., Yu, L., et al., Intra-and Interpopulation Diversity at Short Tandem Repeat Loci in Diverse Population of the World, Electrophoresis (Weinheim, Fed. Repub. Ger.), 1995, vol. 16, pp. 1659–1664.

    Google Scholar 

  10. Destro-Bisol., G., Maviglia, R., Caglia, A., et al., Estimating European Admixture in African Americans by Using Microsatellites and a Microsatellite Haplotype (CD4/Alu), Hum. Genet., 1999, vol. 104, pp. 149–157.

    Google Scholar 

  11. Bosch, E., Calafell, F., Perez-Lezaun, A., et al., Genetic Structure of Northwest Africa Revealed by STR Analysis, Eur. J. Hum. Genet., 2000, vol. 8, pp. 360–366.

    Google Scholar 

  12. Bowcock, A., Ruiz-Linares, A., Tomfohrde, J., et al., High Resolution of Human Evolutionary Trees with Polymorphic Microsatellites, Nature, 1994, vol. 386, pp. 455–457.

    Google Scholar 

  13. Jorde, L., Bamshard, M., Witkins, W., et al., Origins and Affinities of Modern Humans: A Comparison of Mitochondrial and Nuclear Genetic Data, Am. J. Hum. Genet., 1995, vol. 57, pp. 523–538.

    Google Scholar 

  14. Goldstein, D., Riuz Linares, A., Cavalli-Sforza, L., and Feldman, M., An Evaluation of Genetic Distances for Use with Microsatellite Loci, Genetics, 1995, vol. 139, pp. 463–471.

    Google Scholar 

  15. Di Renzo, A., Donnelly, P., Toomajian, C., et al., Heterogeneity of Microsatellite Mutations within and between Loci and Implications for Human Demographic Histories, Genetics, 1998, vol. 148, pp. 1269–1284.

    Google Scholar 

  16. Gill, P., Ivanov, P., Kimpton, C., et al., Identification of the Remains of the Romanov Family by DNA Analysis, Nat. Genet., 1994, vol. 6, pp. 130–135.

    Google Scholar 

  17. Urquhart, A., Kimpton, C., Downes, T., and Gill, P., Variation in Short Tandem Repeat Sequences-A Survey of Twelve Microsatellite Loci for Use as Forensic Identification Markers, Int. J. Legal Med., 1994, vol. 107, pp. 13–20.

    Google Scholar 

  18. Bar, W., Brinkmann, B., Budowle, B., et al., DNA Recommendations: Further Report of the DNA Commission of the ISHF Regarding the Use of Short Tandem Repeat Systems, Int. J. Legal Med., 1997, vol. 110, pp. 175–176.

    Google Scholar 

  19. Stepanov, V.A. and Puzyrev, V.P., Population Genetic Analysis of Four Microsatellite Loci in the Tuva Population, Byull. Eksp. Biol. Med., 2000, vol. 129, suppl. 1, pp. 56–58.

    Google Scholar 

  20. Stepanov, V.A., Puzyrev, V.P., Spiridonova, M.G., and Khitrinskaya, I.Yu., Analysis of the Alu Insertion Polymorphism in the Urban and Rural Populations of Siberia, Genetika (Moscow), 1999, vol. 35, no. 8, pp. 1138–1143.

    Google Scholar 

  21. Khitrinskaya, I.Yu., Stepanov, V.A., and Puzyrev, V.P., Analysis of the Alu Polymorphism in Buryat Populations, Genetika (Moscow), 2001, vol. 37, no. 11, pp. 1553–1558.

    Google Scholar 

  22. Stepanov, V.A., Khitrinskaya, I.Yu., and Puzyrev, V.P., Genetic Differentiation of the Tuva Population with Respect to Polymorphic Alu Insertions, Genetika (Moscow), 2001, vol. 37, no. 4, pp. 563–569.

    Google Scholar 

  23. Stepanov, V.A. and Puzyrev, V.P., Microsatellite Haplotypes of the Y Chromosome Revealed No Subdivision but Several Components of the Male Gene Pool of Tuvinians, Genetika (Moscow), 2000, vol. 36, no. 3, pp. 377–384.

    Google Scholar 

  24. Weissenbach, J., Gyapay, G., Dib, C., et al., A Second-Generation Linkage Map of the Human Genome, Nature 1992, vol. 359, pp. 794–801.

    Google Scholar 

  25. Gyapay, G., Morisette, J., and Vignal, A., Genethon Human Genetic Linkage Map, Nat. Genet. 1994, vol. 7, pp. 246–339.

    Google Scholar 

  26. Guo, S. and Thomson, E., Performing the Exact Test of Hardy-Weinberg Proportion for Multiple Alleles, Biometrics 1992, vol. 48, pp. 361–372.

    Google Scholar 

  27. Excoffier, L., Smouse, P., and Quattro, J., Analysis of Molecular Variance Inferred from Metric Distances among DNA Haplotypes: Application to Human Mitochondrial DNA Restriction Data, Genetics 1992, vol. 13, pp. 479–491.

    Google Scholar 

  28. Kucher, A.N., Puzyrev, V.P., Sanchat, N.O., and Erdynieva, L.S., Genetic Demographical Characterization of the Rural Population of the Tuva Republic: Marriage Structure, Inbreeding, Genetika (Moscow), 1999, vol. 35, no. 7, pp. 976–981.

    Google Scholar 

  29. Puzyrev, V.P., Erdynieva, L.S., Kucher, A.N., and Nazarenko, L.P., Genetiko-epidemiologicheskoe issledovanie naseleniya Tuvy (Genetic Epidemiological Study of the Tuva Population), Tomsk, 1999.

  30. Barbuhani, G., Magagni, A., Minch, E., and Cavalli-Sforza, L., An Appointment of Human DNA Diversity, Proc. Natl. Acad. Sci. USA, 1997, vol. 94, pp. 4516–4519.

    Google Scholar 

  31. Perez-Lezaun, A., Calafell, F., Seielstad, M., et al., Population Genetics of Y-Chromosome Short Tandem Repeats in Human, J. Mol. Evol. 1997, vol. 45, pp. 265–270.

    Google Scholar 

  32. Eller, E., Population Substructure and Isolation by Distance in Three Continental Regions, Am. J. Phys. Anthropol., 1999, vol. 108, pp. 147–159.

    Google Scholar 

  33. Slatkin, M., A Measure of Population Subdivision Based on Microsatellite Frequencies, Genetics, 1995, vol. 139, pp. 457–462.

    Google Scholar 

  34. Lum, K., Cann, R., Martinson, J., and Jorde, L., Mitochondrial and Nuclear Genetic Relationships among Pacific Islands and Asian Populations, Am. J. Hum. Genet. 1998, vol. 63, pp. 613–624.

    Google Scholar 

  35. Potapov, L., Ocherki narodnogo byta tuvintsev (Essays on the Traditional Everyday Life of Tuvinians), Moscow: Nauka, 1969.

    Google Scholar 

  36. Serdobov, N., Istoriya formirovaniya tuvinskoi natsii (History of the Formation of Tuvinians), Kyzyl, 1971.

  37. Vainshtein, S., Istoricheskaya etnografiya tuvintsev (Historical Ethnography of Tuvinians), Moscow: Nauka, 1972.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Medical Genetics, Russian Academy of Medical Sciences, Tomsk, 634050, Russia

    V. A. Stepanov, M. G. Spiridonova, V. N. Tadinova & V. P. Puzyrev

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  1. V. A. Stepanov
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  2. M. G. Spiridonova
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  3. V. N. Tadinova
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  4. V. P. Puzyrev
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Stepanov, V.A., Spiridonova, M.G., Tadinova, V.N. et al. Analysis of Genetic Diversity of North Eurasian Populations Using Autosomal Microsatellite Loci. Russian Journal of Genetics 39, 1168–1174 (2003). https://doi.org/10.1023/A:1026131128619

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