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Relationship between Glutathione S-Transferase P1 Polymorphism and Bronchial Asthma and Atopic Dermatitis

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Abstract

We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).

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Authors and Affiliations

  1. Siberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and Biophysics, Russia

    O. G. Safronova, V. A. Vavilin, A. A. Lyapunova, S. I. Makarova, V. V. Lyakhovich, L. F. Kaznacheeva, N. A. Manankin, O. A. Batychko & S. M. Gavalov

  2. Novosibirsk State Medical Academy, Russia

    V. A. Vavilin, A. A. Lyapunova, S. I. Makarova, V. V. Lyakhovich, L. F. Kaznacheeva, N. A. Manankin, O. A. Batychko & S. M. Gavalov

  3. Municipal Children's Hospital No. 1, Novosibirsk

    V. A. Vavilin, A. A. Lyapunova, S. I. Makarova, V. V. Lyakhovich, L. F. Kaznacheeva, N. A. Manankin, O. A. Batychko & S. M. Gavalov

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  1. O. G. Safronova
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  2. V. A. Vavilin
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  3. A. A. Lyapunova
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  4. S. I. Makarova
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  5. V. V. Lyakhovich
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  6. L. F. Kaznacheeva
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  7. N. A. Manankin
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  8. O. A. Batychko
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  9. S. M. Gavalov
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Correspondence to O. G. Safronova.

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Safronova, O.G., Vavilin, V.A., Lyapunova, A.A. et al. Relationship between Glutathione S-Transferase P1 Polymorphism and Bronchial Asthma and Atopic Dermatitis. Bulletin of Experimental Biology and Medicine 136, 73–75 (2003). https://doi.org/10.1023/A:1026001216033

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  • DOI: https://doi.org/10.1023/A:1026001216033

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