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The Role of Region pX in the Life Cycle of HTLV-I and in Carcinogenesis

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Abstract

The review considers the molecular biological organization of genome region pX of the human T-cell leukemia virus type I (HTLV-I) along with the structure and functions of regulatory proteins Tax, Rex, and poorly studied Rof and Tof. Tax functions are described, including transcriptional trans-activation, trans-repression, and effects on apoptosis and the cell cycle. The roles of Tax and Rex in controlling gene expression and replication of HTLV-I are discussed.

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  1. Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia

    O. Yu. Susova & V. E. Gurtsevich

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  1. O. Yu. Susova
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  2. V. E. Gurtsevich
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Susova, O.Y., Gurtsevich, V.E. The Role of Region pX in the Life Cycle of HTLV-I and in Carcinogenesis. Molecular Biology 37, 334–344 (2003). https://doi.org/10.1023/A:1024270823472

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  • DOI: https://doi.org/10.1023/A:1024270823472

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