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Serum lipid levels in an Iranian adults population: Tehran lipid and glucose study

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Abstract

Data from 6246 participants aged 20–64 years (2339 males and 3907 females) in the cross-sectional phase of Tehran Lipid and Glucose Study (February 1999–May 2000) were used to determine distribution of serum lipid levels after 12–14 hour overnight fast. Mean total cholesterol (TC) concentration was 210 mg/dl. TC was significantly greater in females than males, 213 and 206 mg/dl, respectively (p < 0.0001). Thirty-one percent of population had TC values between 200 and 239 and 24% had values of 240 mg/dl or greater. Mean low-density lipoprotein cholesterol (LDL-C) was 129 and 135 mg/dl in males and females, respectively (p < 0.0001). Twenty-seven percent had LDL-C values between 130 and 159 and 23% had values 160 mg/dl or greater. The mean triglycerides (TGs) values were 190 and 162 mg/dl for males and females, respectively (p < 0.0001). The mean high-density lipoprotein cholesterol (HDL-C) was 39 in males and 45 mg/dl in females (p < 0.0001). The results showed higher levels of TC, LDL-C and TGs and slightly lower HDL-C in Tehranian adults than other studies in the industrialized countries.

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References

  1. Heyden S. Epidemiolgy. In: Schettler FG, Boyd GS (eds), Atherosclerosis. Pathology, Physiology, Aethiology, Diagnosis, and Clinical Management. New York: Elsevier Publishing Company, 1969; 774–860.

    Google Scholar 

  2. Stamler J. Established major coronary risk factors. In: Marmot M, Elliot P (eds), Coronary Heart Disease Epidemiolgy. Oxford: Oxford University Press, 1992; 774–860.

    Google Scholar 

  3. Wilson PW, Abbott RD, Castelli WP. High-density lipoprotein cholesterol and mortality. The Framingham Heart Study. Arteriosclerosis 1988; 8: 737–741.

    Google Scholar 

  4. Triglyceride, high-density lipoprotein, and coronary heart disease. NIH Consensus Development Panel on triglyceride, high-density lipoprotein, and coronary heart disease. JAMA 1993; 269: 505–510.

  5. The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 1984; 251: 351–364.

    Google Scholar 

  6. The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 1984; 251: 365–374.

    Google Scholar 

  7. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383–1389.

  8. Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995; 333: 1301–1307.

    Google Scholar 

  9. Haskell WL, Alderman EL, Fair JM, et al. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP). Circulation 1994; 89: 975–990.

    Google Scholar 

  10. Puska P, Nissinen A, Tuomilehto J, et al. The community-based strategy to prevent coronary heart disease: Conclusions from the ten years of the North Karelia project. Ann Rev Public Health 1985; 6: 147–93.

    Google Scholar 

  11. Vartiainen E, Puska P, Pekkanen J, Tuomilehto J, Jousilahti. Changes in risk factors explain changes in mortality from ischaemic heart disease in Finland. Br Med J 1994; 309: 23–27.

    Google Scholar 

  12. Triglyceride, high-density lipoprotein, and coronary heart disease. NIH Consensus conference. NIH Consensus Development Panel on triglyceride, high-density lipoprotein, and coronary heart disease. JAMA 1993; 269: 505–510.

  13. Pelkonen R, Nikkila EA, Koskinen S, Penttinen K, Sarna S. Association of serum lipids and obesity with cardiovascular mortality. Br Med J 1977; 2: 1185–1187.

    Google Scholar 

  14. Janus ED, Postiglione A, Singh RB, Lewis B. The modernization of Asia. Implications for coronary heart Federation of Cardiology. Circulation 1996; 94: 2671–2673.

    Google Scholar 

  15. Keys A. Seven Countries: A Multivariate Analysis Death and Coronary Heart Disease. Cambridge, MA: Harvard University Press; 1980.

    Google Scholar 

  16. Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 1986; 256: 2823–2828.

    Google Scholar 

  17. Verschuren WM, Jacobs DR, Bloemberg BP, et al. Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven. JAMA 1995; 274: 131–136.

    Google Scholar 

  18. Singh RB, Ghosh S, Niaz AM, et al. Epidemiologic study of diet and coronary risk factors in relation to central obesity and insulin levels in rural and urban populations of north India. Int J Cardiol 1995; 47: 245–255.

    Google Scholar 

  19. Indian Consensus Group. Indian consensus for prevention of hypertension and coronary artery disease. J Nutr Med 1996; 6: 309–318.

    Google Scholar 

  20. Goldbourt U, Holtzman E, Neufeld HN. Total and high density lipoprotein cholesterol in the serum and risk of mortality: Evidence of a threshold effect. Br Med J 1985; 290: 1239–1243.

    Google Scholar 

  21. Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 1998; 81: 7B–12B.

    Google Scholar 

  22. Seftel HC. The rarity of coronary heart disease in South African blacks. S Afr Med J 1978; 54: 99–105.

    Google Scholar 

  23. Navai L, Mehrabi Y, Kimiagar M, Azizi F. Epidemiologic survey on hypertension and its relation with obesity, diabetes, and hyperlipidemia in Islamshahr, Iran. Pajouhesh dar Pezeshki 1998; 22: 71–80 (Farsi).

    Google Scholar 

  24. Rafei M, Boshtam M, Sarafzadegan N. Lipid profiles in the Isfahan population: An Isfahan cardiovascular disease risk factor survey, 1994. East Med Health J 1999; 5: 766–777.

    Google Scholar 

  25. Azizi F, Rahmani M, Emami H, Madjid M. Tehran Lipid and Glucose Study: Rationale and Design. CVD Prevention 2000; 3: 242–47.

    Google Scholar 

  26. Azizi F, Rahmani M, Madjid M, et al. Serum lipid levels in an Iranian population of children and adolescents: Tehran lipid and glucose study. Eur J Epidemiol 2001; 17: 281–88.

    Google Scholar 

  27. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499–502.

    Google Scholar 

  28. MacLean DR, Petrasovits A, Connelly PW, Joffres M, O'Connor B, Little JA. Plasma lipids and lipoprotein reference values, and the prevalence of dyslipoproteinemia in Canadian adults. Canadian Heart Health Surveys Research Group. Can J Cardiol 1999; 15: 434–444.

    Google Scholar 

  29. Johnson CL, Rifkind BM, Sempos CT, et al. Declining serum total cholesterol levels among US adults. The National Health and Nutrition Examination Surveys. JAMA 1993; 269: 3002–3008.

    Google Scholar 

  30. The Lipid Research Clinics Epidemiology committee. Plasma lipid distribution in selected North American populations: The Lipid Research Clinics Program Prevalence Study. Circulation 1979; 60: 427–439.

    Google Scholar 

  31. Jones GJ, Hewitt D, Godin GJ, et al. Plasma lipoprotein levels and the prevalence of hyperlipoproteinemia in a Canadian working population. Can Med Assoc J 1980; 122: 37–38, 40-46.

    Google Scholar 

  32. Davis CE, Williams DH, Oganov RG, et al. Sex difference in high-density lipoprotein cholesterol in six countries. Am J Epidemiol 1996; 143: 1100–1116.

    Google Scholar 

  33. Heiss G, Tamir I, Davis CE, et al. Lipoprotein-cholesterol distributions in selected North American populations: The lipid research clinics program prevalence study. Circulation 1980; 61: 302–315.

    Google Scholar 

  34. Distribution of some risk factors for atherosclerosis in nine Italian population samples. The Research Group ATS-RF2 of the Italian National Research Council. Am J Epidemiol 1981; 113: 338–346.

    Google Scholar 

  35. Grundy SM. George Lyman Duff Memorial Lecture. Multifactorial etiology of hypercholesterolemia. Implications for prevention of coronary heart disease. Arterioscler Thromb 1991; 11: 1619–1635.

    Google Scholar 

  36. Sekimoto H, Goto Y, Naito C, et al. Changes of serum total cholesterol and triglyceride levels in normal subjects in Japan in the past twenty years. Research committee on familial hyperlipidemia in Japan. Jpn Circ J 1983; 47: 1351–1358.

    Google Scholar 

  37. Chen H, Zhuang H, Han Q. Serum high density lipoprotein cholesterol and factors influencing its level in healthy Chinese. Atherosclerosis 1983; 48: 71–79.

    Google Scholar 

  38. Thgamson GR. A Handbook of Hyperlipidemeia. London: Current Science Ltd, 1990.

    Google Scholar 

  39. Geographical variation in the major risk factors of coronary heart disease in men and women aged 35-64 years. The WHO MONICA Project. World Health Stat Q 1988; 41: 115–140.

  40. Al-Nuaim AR, al-Rubeaan K, al-Mazrou Y, al-Attas O, al-Daghari. Prevalence of hypercholesterolemia in Saudi Arabia, epidemiological study. Int J Cardiol 1996; 54: 41–49.

    Google Scholar 

  41. Austin MA. Plasma triglyceride and coronary heart disease. Arterioscler Thromb 1991; 11: 2–14.

    Google Scholar 

  42. Castelli WP. The triglyceride issue: A view from Framingham. Am Heart J 1986; 112: 432–437.

    Google Scholar 

  43. Carleton RA, Dwyer J, Finberg L, et al. Report of the Expert Panel on Population Strategies for Blood Cholesterol Reduction. A statement from the National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health. Circulation 1991; 83: 2154–2232.

    Google Scholar 

  44. Beaglehole R, La Rosa, Heiss G, et al. Serum cholesterol, diet, and the decline in coronary heart disease mortality. Prev MED 1991; 324: 941–946.

    Google Scholar 

  45. Onat A, Surdum-Avci G, Senocak M, Ornek E, Gozukara Y. Plasma lipids and their interrelationship in Turkish adults. J Epidemiol Community Health 1992; 46: 470–476.

    Google Scholar 

  46. Mann JI, Lewis B, Shepherd J, et al. Blood lipid concentrations and other cardiovascular risk factors: Distribution, prevalence, and detection in Britain. Br Med J 1988; 296: 1702–1706.

    Google Scholar 

  47. Sempos CT, Cleeman JI, Carroll MD, et al. Prevalence of high blood cholesterol among US adults. An update based on guidelines from the second report of the National Cholesterol Education Program Adult Treatment Panel. JAMA 1993; 269: 3009–3014.

    Google Scholar 

  48. Reeder BA, Angel A, Ledoux M, Rabkin SW, Young TK, Sweet LE. Obesity and its relation to cardiovascular disease risk factors in Canadian adults. Canadian Heart Health Surveys Research Group. CMAJ 1992; 146: 2009–2019.

    Google Scholar 

  49. Singh RB, Rastogi V, Niaz MA, Ghosh S, Sy RG, Janus ED. Serum cholesterol and coronary artery disease in populations with low cholesterol levels: The Indian paradox. Int J Cardiol 1998; 65(1): 81–90.

    Google Scholar 

  50. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 1977; 62: 707–714.

    Google Scholar 

  51. Gordon DJ, Probstfield JL, Garrison RJ, et al. Highdensity lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 1989; 79: 8–15.

    Google Scholar 

  52. Gordon DJ, Rifkind BM. High-density lipoprotein. N Engl J Med 1989; 321: 1311–1316.

    Google Scholar 

  53. Gordon DJ, Knoke J, Probstfield JL, Superko R, Tyroler HA. High-density lipoprotein cholesterol and coronary heart disease in hypercholesterolemic men: The Lipid Research Clinics Coronary Primary Prevention Trial. Circulation 1986; 74: 1217–1225.

    Google Scholar 

  54. Abbott RD, Wilson PW, Kannel WB, Castelli WP. High-density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham Study. Arteriosclerosis 1988; 8: 207–211.

    Google Scholar 

  55. Castelli WP, Anderson K. A population at risk. Prevalence of high cholesterol levels in hypertensive patients in the Framingham Study. Am J Med 1986; 80: 23–32.

    Google Scholar 

  56. Castelli WP, Wilson PW, Levy D, Anderson K. Cardiovascular risk factors in the elderly. Am J Cardiol 1989; 63: 12H–19H.

    Google Scholar 

  57. Linn S, Fulwood R, Rifkind B, et al. High density lipoprotein cholesterol levels among US adults by selected demographic and socioeconomic variables. The Second National Health and Nutrition Examination Survey 1976-1980. Am J Epidemiol 1989; 129: 281–294.

    Google Scholar 

  58. Heiss G, Johnson NJ, Reiland S, Davis CE, Tyroler HA. The epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Research Clinics Program Prevalence Study. Summary. Circulation 1980; 62: 116–136.

    Google Scholar 

  59. Jacobs DR Jr, Mebane IL, Bangdiwala SI, Criqui MH, Tyroler HA. High-density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women: The follow up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol 1990; 131: 32–47.

    Google Scholar 

  60. Levy D, Wilson PW, Anderson KM, Castelli WP. Stratifying the patient at risk from coronary disease: New insights from the Framingham Heart Study. Am Heart J 1990; 119: 712–717.

    Google Scholar 

  61. Bush TL, Fried LP, Barrett-Connor E. Cholesterol, lipoproteins, and coronary heart disease in women. Clin Chem 1988; 34: B60–B70.

    Google Scholar 

  62. US Department of Health and Human Services, Public Health Service. National Cholesterol Education Program: highlights of the Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. National Institutes of Health, National Heart, Lung, and Blood Institute. J Am Osteopath Assoc 1992; 92: 380–388.

    Google Scholar 

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  1. Endocrine and Metabolism Research Centre, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

    F. Azizi, M. Rahmani, A. Ghanbarian, H. Emami, P. Salehi, P. Mirmiran & N. Sarbazi

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Azizi, F., Rahmani, M., Ghanbarian, A. et al. Serum lipid levels in an Iranian adults population: Tehran lipid and glucose study. Eur J Epidemiol 18, 311–319 (2003). https://doi.org/10.1023/A:1023606524944

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