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A System-Approach Method for the Adjustment of Time-Varying Continuous Drug Infusion in Individual Patients: A Simulation Study

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Abstract

The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration–time profiles in patients. The method presented can be used for safe and cost-effective individualization of drug dosing by computer-controlled infusion pumps. Utilization of this method is exemplified by simulation experiments, aimed at adjusting continuous infusions of Factor VIII (FVIII) at time-varying rates, which would theoretically yield required concentration–time profiles of FVIII in hemophilia A patients over several days.

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Authors and Affiliations

  1. Institute of Experimental Pharmacology, Slovak Academy of Sciences, 841 04, Bratislava, Slovak Republic

    Mária Ďurišová

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  1. Mária Ďurišová
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  2. Ladislav Dedík
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Correspondence to Mária Ďurišová.

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Ďurišová, M., Dedík, L. A System-Approach Method for the Adjustment of Time-Varying Continuous Drug Infusion in Individual Patients: A Simulation Study. J Pharmacokinet Pharmacodyn 29, 427–444 (2002). https://doi.org/10.1023/A:1022968319095

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