Abstract
Rearrangements of the parameters of the electric activity of the cortical and subcortical regions were studied at different stages of experimental hypoxia (exposure to oxygen–nitrogen mixtures with an oxygen content of 7.5–8.0%) in chronic experiments of rabbits with the use of electrodes implanted into the brain. Acute hypoxia was shown to cause characteristic changes in electrical activity in the cortex, reticular formation, caudate nuclei, and hippocampus. The sequence of these changes may be divided into the following stages: (1) a short-term activation of all cerebral structures during the first 15–30 s and a shift of the frequency spectrum towards higher frequencies (β and α waves), (2) a decrease in β and α waves and an increase in θ activity during the next 2–4 min, and (3) a gradual shift towards slow waves (the Δ rhythm) and paroxysmal episodes in some animals. These shifts first appear in the frontal cortical regions and the reticular formation and then in the caudate nuclei and hippocampus. The degree of the changes in electric activity is correlated with the decrease in oxygen tension in the arterial blood.
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Soroko, S.I., Dzhunusova, G.S. Rearrangements of the Total Electric Activity of the Cerebral Cortex and Subcortical Structures in Experimental Hypoxia. Human Physiology 29, 1–7 (2003). https://doi.org/10.1023/A:1022032014380
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DOI: https://doi.org/10.1023/A:1022032014380