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Multiple Autoantibodies Associated with Autoimmune Reproductive Failure

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Abstract

Purpose : Autoimmune factors are involved in some of the cases of reproductive failure. The aim of this paper is to discuss the association between autoantibodies and reproductive failure.

Methods : Literature review of autoantibodies associated with reproductive failure.

Results : Several autoantibodies were found in association with such clinical manifestations, mainly in patients having systemic lupus erythematosus or the antiphospholipid syndrome. These autoantibodies include “classical” antiphospholipid antibodies such as anticardiolipin, anti-β2-glycoprotein-I, antiphosphatidylserine, and antiphosphatidylethanolamine. There are also some “nonclassical” antiphospholipid antibodies directed to prothrombin, thromboplastin, or mitochondrial antibodies of M5 type, which were also found in patients with reproductive failure. Moreover, animal models as well as some human studies support a role for other autoantibodies in these clinical manifestations including antithyroglobulin, antilaminin-1, anti-corpus luteum, antiprolactin, anti-poly(ADP-ribose), and lymphocytotoxic antibodies.

Conclusions : Even though there is not enough data currently to support a firm association between some of these autoantibodies and reproductive failure, future studies are likely to help us determine and expand the number of autoantibodies screened in these patients.

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Authors and Affiliations

  1. Department of Medicine “B,”, Sheba Medical Center, Tel-Hashomer, Israel

    Yaniv Sherer & Yehuda Shoenfeld

  2. Center of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel

    Yaniv Sherer, Shelly Tartakover-Matalon, Miri Blank & Yehuda Shoenfeld

  3. Sackler Faculty of Medicine, Tel-Aviv University, Israel

    Yaniv Sherer, Miri Blank & Yehuda Shoenfeld

  4. Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, Japan

    Eiji Matsuura

Authors
  1. Yaniv Sherer
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  2. Shelly Tartakover-Matalon
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  3. Miri Blank
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  4. Eiji Matsuura
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  5. Yehuda Shoenfeld
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Sherer, Y., Tartakover-Matalon, S., Blank, M. et al. Multiple Autoantibodies Associated with Autoimmune Reproductive Failure. J Assist Reprod Genet 20, 53–57 (2003). https://doi.org/10.1023/A:1021716623305

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  • DOI: https://doi.org/10.1023/A:1021716623305

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