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Reduced Expression of αvβ3 Integrin in the Endometrium of Unexplained Infertility Patients with Recurrent IVF-ET Failures: Improvement by Danazol Treatment

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Abstract

Purpose : To determine whether there is any association between the expression of endometrial integrin α v β3 and repeated IVF-ET failure and to examine the effect of danazol treatment on α v β3 expression.

Methods : This prospective study was performed using a semiquantitative immunohistochemical analysis on the staining intensity of α v β3 in the mid-secretory endometria derived from 10 fertile women and 57 infertile patients with a history of repeated IVF-ET failures. Nine patients randomly selected from these 22 patients with unexplained infertility were then treated with oral danazol administration for 12 weeks and reexamined at the first mid-secretory phase after the danazol treatment.

Result(s) : The levels of endometrial α v β3 expression were lower in 22 patients with unexplained infertility than in the fertile control and 35 patients with explained infertility. The 9 patients treated with danazol showed a significant increase in the α v β3 staining.

Conclusion(s) : The significantly decreased expression of endometrial integrin α v β3 suggested that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility. Danazol may have a therapeutic potential in improving endometrial function together with up-regulation of α v β3.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan

    Chisei Tei, Tetsuo Maruyama, Naoaki Kuji, Toyohiko Miyazaki & Yasunori Yoshimura

  2. Department of Obstetrics and Gynecology, National Saitama Hospital, Saitama, Japan

    Mikio Mikami

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  1. Chisei Tei
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  2. Tetsuo Maruyama
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  3. Naoaki Kuji
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  4. Toyohiko Miyazaki
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  5. Mikio Mikami
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  6. Yasunori Yoshimura
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Tei, C., Maruyama, T., Kuji, N. et al. Reduced Expression of αvβ3 Integrin in the Endometrium of Unexplained Infertility Patients with Recurrent IVF-ET Failures: Improvement by Danazol Treatment. J Assist Reprod Genet 20, 13–20 (2003). https://doi.org/10.1023/A:1021254620888

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