Skip to main content
Log in

Polymorphism of Glutathione S-Transferase Genes M1 and T1 in Patients with Motor Neuron Disease from the Moscow Population

  • Published:
Russian Journal of Genetics Aims and scope Submit manuscript

Abstract

Comparison of the frequency distributions of alleles, genotypes, and genotype combinations of genes GSTM1and GSTT1 did not show statistically significant differences between patients with motor neuron disease (MND) and a random sample from the Moscow population. Apparently, these genes are not involved in MND pathogenesis in these patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. Zavalishin, I.A. and Zakharova, M.N., Amyotrophic Lateral Sclerosis, Zh. Nevrol. Psikhiatr. im. S.S. Korsakova, 1999, vol. 99, no. 4, pp. 60–64.

    Google Scholar 

  2. Julien, J.-P., Amyotrophic Lateral Sclerosis: Unfolding the Toxicity of the Misfolded, Cell (Cambridge, Mass.), 2001, vol. 104, pp. 581–591.

    Article  PubMed  Google Scholar 

  3. Baranov, V.S., Baranova, V.E., Ivashchenko, T.E., and Aseev, M.V., The Human Genome and “Predisposition” Genes, Vvedenie v prediktivnuyu meditsinu (Introduction to Predictive Medicine), St. Petersburg: Inter-medika, 2000.

    Google Scholar 

  4. Xu, S., Wang, Y., Roe, B., et al., Characterization of the Human Class Mu Glutathione S-Transferase Gene Cluster and the GSTM1 Deletion, J. Biol. Chem., 1998, vol. 273, no. 6, pp. 3517–3527.

    PubMed  Google Scholar 

  5. Ivashchenko, T.E., Sideleva, O.G., Petrova, M.A., et al., Genetic Factors in Susceptibility to Bronchial Asthma, Genetika (Moscow), 2001, vol. 37, no. 1, pp. 107–111.

    PubMed  Google Scholar 

  6. Seidegard, J., Pero, R.W., Markowits, M.M., et al., Isozyme of Glutathione S-Transferase (Class Mu) as a Marker of the Susceptibility to Lung Cancer: A Follow-Up Study, Carcinogenesis, 1999, vol. 11, no. 1, pp. 33–36.

    Google Scholar 

  7. Baranova, H., Bothorishvilli, R., Canis, M., et al., Glu-tathione S-Transferase M1 Gene Polymorphism and Susceptibility to Endometriosis in a French Population, Mol. Hum. Reprod., 1997, vol. 3, no. 9, pp. 775–780.

    PubMed  Google Scholar 

  8. Sambrook, J., Fritsch, E.F., and Maniatis, T., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, New York: Cold Spring Harbor Lab., 1989, p. 923.

    Google Scholar 

  9. Seidegard, J., Vorachek, W.R., Pero, R.V., and Pear-son, W.R., Hereditary Differences in the Expression of the Human Glutathione Transferase Active on Trans-Stilben Oxide Are Due to a Gene Deletion, Proc. Natl. Acad. Sci. USA, 1988, vol. 85, pp. 7293–7297.

    PubMed  Google Scholar 

  10. Nicholl, D.J., Bennett, P., Vanacore, N., et al., A Study of Five Candidate Genes in Parkinson's Disease and Related Neurodegenerative Disorders: European Study Group on Atypical Parkinsonism, Neurology, 1999, vol. 53, no. 7, pp. 1415–1421.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shadrina, M.I., Kondratyeva, E.A., Slominsky, P.A. et al. Polymorphism of Glutathione S-Transferase Genes M1 and T1 in Patients with Motor Neuron Disease from the Moscow Population. Russian Journal of Genetics 38, 1327–1329 (2002). https://doi.org/10.1023/A:1021115631563

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1021115631563

Keywords

Navigation