Abstract
Comparison of the frequency distributions of alleles, genotypes, and genotype combinations of genes GSTM1and GSTT1 did not show statistically significant differences between patients with motor neuron disease (MND) and a random sample from the Moscow population. Apparently, these genes are not involved in MND pathogenesis in these patients.
Similar content being viewed by others
REFERENCES
Zavalishin, I.A. and Zakharova, M.N., Amyotrophic Lateral Sclerosis, Zh. Nevrol. Psikhiatr. im. S.S. Korsakova, 1999, vol. 99, no. 4, pp. 60–64.
Julien, J.-P., Amyotrophic Lateral Sclerosis: Unfolding the Toxicity of the Misfolded, Cell (Cambridge, Mass.), 2001, vol. 104, pp. 581–591.
Baranov, V.S., Baranova, V.E., Ivashchenko, T.E., and Aseev, M.V., The Human Genome and “Predisposition” Genes, Vvedenie v prediktivnuyu meditsinu (Introduction to Predictive Medicine), St. Petersburg: Inter-medika, 2000.
Xu, S., Wang, Y., Roe, B., et al., Characterization of the Human Class Mu Glutathione S-Transferase Gene Cluster and the GSTM1 Deletion, J. Biol. Chem., 1998, vol. 273, no. 6, pp. 3517–3527.
Ivashchenko, T.E., Sideleva, O.G., Petrova, M.A., et al., Genetic Factors in Susceptibility to Bronchial Asthma, Genetika (Moscow), 2001, vol. 37, no. 1, pp. 107–111.
Seidegard, J., Pero, R.W., Markowits, M.M., et al., Isozyme of Glutathione S-Transferase (Class Mu) as a Marker of the Susceptibility to Lung Cancer: A Follow-Up Study, Carcinogenesis, 1999, vol. 11, no. 1, pp. 33–36.
Baranova, H., Bothorishvilli, R., Canis, M., et al., Glu-tathione S-Transferase M1 Gene Polymorphism and Susceptibility to Endometriosis in a French Population, Mol. Hum. Reprod., 1997, vol. 3, no. 9, pp. 775–780.
Sambrook, J., Fritsch, E.F., and Maniatis, T., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, New York: Cold Spring Harbor Lab., 1989, p. 923.
Seidegard, J., Vorachek, W.R., Pero, R.V., and Pear-son, W.R., Hereditary Differences in the Expression of the Human Glutathione Transferase Active on Trans-Stilben Oxide Are Due to a Gene Deletion, Proc. Natl. Acad. Sci. USA, 1988, vol. 85, pp. 7293–7297.
Nicholl, D.J., Bennett, P., Vanacore, N., et al., A Study of Five Candidate Genes in Parkinson's Disease and Related Neurodegenerative Disorders: European Study Group on Atypical Parkinsonism, Neurology, 1999, vol. 53, no. 7, pp. 1415–1421.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shadrina, M.I., Kondratyeva, E.A., Slominsky, P.A. et al. Polymorphism of Glutathione S-Transferase Genes M1 and T1 in Patients with Motor Neuron Disease from the Moscow Population. Russian Journal of Genetics 38, 1327–1329 (2002). https://doi.org/10.1023/A:1021115631563
Issue Date:
DOI: https://doi.org/10.1023/A:1021115631563