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Extinction of Operant Behavior as the Test for Cognitive Disorders Induced with Kainic Acid

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Abstract

Wistar rats were trained food-procuring task for 5 days and then extinction of the operant behavior was studied for 6 days after injection of an epileptogen (kainic acid, 8 mg/kg, intraperitoneally). Kainic acid induced long-term impairment of inhibitory processes in the brain, which impeded extinction of a conditioned response. This effect was prevented by daily injections of anticonvulsant sodium valproate (300 mg/kg for 4 days).

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Authors and Affiliations

  1. Laboratory of Synaptic Transmission Mechanisms, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Puschino, Russia

    V. I. Arkhipov & N. A. Shevchenko

Authors
  1. V. I. Arkhipov
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  2. N. A. Shevchenko
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Correspondence to V. I. Arkhipov.

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Arkhipov, V.I., Shevchenko, N.A. Extinction of Operant Behavior as the Test for Cognitive Disorders Induced with Kainic Acid. Bulletin of Experimental Biology and Medicine 133, 553–555 (2002). https://doi.org/10.1023/A:1020269406061

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  • DOI: https://doi.org/10.1023/A:1020269406061

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