The Measurement of Mixture Homogeneity and Dissolution to Predict the Degree of Drug Agglomerate Breakdown Achieved Through Powder Mixing

Abstract

Interactive mixing of agglomerates of small, cohesive particles with coarse carrier particles facilitate the deaggregation of agglomerates. In this study dispersion of agglomerates of microfine furosemide particles by such a mixing process was followed by measuring changes in the content uniformity and area under the dissolution curve. Interactive mixtures between agglomerates of different sized furosemide particles and coarse sodium chloride particles were prepared using different mixers, mixing times and mixer speeds. The dissolution rate of the drug from and content uniformity of the mixtures were measured, and degrees of dispersion were calculated. These degrees of dispersion were compared to the dispersion values obtained from the decrease in agglomerate size after mixing. An increase in mixing time led to an increase in dispersion. An initial fast deagglomeration, indicated by an increase in dissolution, increase in content uniformity and a decrease in particle size, was followed by substantially slower deaggregation of remaining agglomerates and smaller aggregates. For all mixtures studied the degree of dispersion estimated from dissolution measurements, when compared to equivalent content uniformity measurements, agreed closely with the degree of dispersion as indicated by the decrease in particle size. The use of the area under the dissolution curve to predict agglomerate breakdown proved useful and may find application in situations where it is impossible to follow directly deagglomeration through particle size measurements.