Abstract
Buccoadhesive controlled-release systems for the delivery of morphine sulfate were prepared by compression of hydroxypropyl methylcellulose (HPMC) with carbomer (CP), which served as the bioactive adhesive compound. The release behavior of systems containing 30 mg of morphine sulfate and various amounts of the two polymers was found to be non-Fickian. The adhesion force was significantly affected by the mixing ratio of HPMC and CP in the tablet, and the weakest adhesion force was observed at a ratio of 1:1 (HPMC:CP). Interpolymer complex formation was confirmed between HPMC and CP in acidic medium by turbidity, viscosity, and FT-IR measurements. The amount absorbed (percentage of the drug loaded) of the controlled-release buccoadhesive tablets in six healthy volunteers and was 30 ± 5%.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
D. Fell, A. Chmielewski, and G. Smith. Postoperative analgesia with controlled-release morphine sulphate, comparison with intramuscular morphine. Br. Med. J. 258:92–94 (1982).
S. F. Brunk and M. S. Delle. Morphine metabolism in man. Clin. Pharmacol. Ther. 1:51–57 (1974).
M. Ishida, Y. Machida, N. Nambu, and T. Nagai. New mucosal dosage form of insulin. Chem. Pharm. Bull. 29:810–816 (1981).
T. Nagai and Y. Machida. Mucosal adhesive dosage forms. Pharm. Int. 6:196–200 (1985).
K. V. Ranga Rao, A. Ben-Amor, and P. Buri. Studies on buccoadhesive tablet formulation of codeine phosphate. STP Pharma 5:899–903 (1989).
A. E. Collins and P. B. Deasy. Bioadhesive lozenge for the improved delivery of cetylpyridinium chloride. J. Pharm. Sci. 79:116–119 (1990).
M. D. D. Bell, P. Mishra, B. D. Weldom, G. R. Murray, T. N. Calvey, and N. E. Williams. Buccal morphine-A new route for analgesia. Lancet 12:71–73 (1985).
A. P. Fisher, P. Vine, J. Whitlock, and M. Hanna. Buccal morphine premedication. Anesthesia 41:1104–1111 (1986).
A. R. Manara, M. P. Shelly, K. G. Quinn, and G. R. Park. Pharmacokinetics of morphine following administration by the buccal route. Br. J. Anaesth. 62:498–502 (1989).
G. Ponchel, F. Touchard, D. Wouessidjewe, D. Duchêne, and N. A. Peppas. Bioadhesive analysis of controlled release systems. III. Bioadhesive and release behaviour of metronidazole containing poly (acrylic acid)-hydroxypropyl methylcellulose systems. Int. J. Pharm. 38:65–70 (1987).
S. Budvari (ed.), The Merck Index, 11th ed., Merck Co. Inc., Rahway, NJ.
M. Bamba, F. Puisieux, and J. P. Marty. Release mechanisms in gel forming sustained release preparations. Int. J. Pharm. 2:307–315 (1979).
K. Çifçi, Y. Çapan, O. Öztürk, and A. A. Hincal. Formulation and in vitro-in vivo evaluation of sustained release lithium carbonate tablets. Pharm. Res. 7:359–363 (1990).
Ş. Anlar, Y. Çapan, and A. A. Hincal. Physico-chemical and bioadhesive properties of polyacrylic acid polymers. Pharmazie 48:285–289 (1993).
N. A. Peppas. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv. 60:110–111 (1985).
K. Takayama, M. Hirata, Y. Machida, T. Masada, T. Saman, and T. Nagai. Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate. Chem. Pharm. Bull. 38:1993–1997 (1990).
P. J. Hoskin, G. W. Hanks, G. W. Aheme, D. Chapman, P. Littleton, and J. Filshie. The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers. Br. J. Clin. Pharmacol. 27:499–505 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Anlar, Ş., Çapan, Y., Güven, O. et al. Formulation and in Vitro–in Vivo Evaluation of Buccoadhesive Morphine Sulfate Tablets. Pharm Res 11, 231–236 (1994). https://doi.org/10.1023/A:1018951323522
Issue Date:
DOI: https://doi.org/10.1023/A:1018951323522