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Salivary Carbonic Anhydrase Protects Gastroesophageal Mucosa from Acid Injury

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Abstract

Saliva contains several factors that protect thealimentary canal mucosa against acidity. We measured thesecretory carbonic anhydrase (CA VI) levels in thesaliva of patients with gastrointestinal disorders using a time-resolved immunofluorometric assay.The mean enzyme concentrations were found to be lower inpatients with verified esophagitis, gastric ulcer, orduodenal ulcer than in control patients with nonacid peptic diseases. The biochemical datafrom the enzyme activity assays and western blots of thehuman gastric mucosa and gastric juice samples indicatedthat the swallowed CA VI probably retains its activity in the harsh environment of thegastric lumen. In the upper alimentary canal, CA VI mayneutralize the acid by catalyzing the formation ofcarbon dioxide and water. The present findings suggest that drugs supplemented with CA VI may provebeneficial in treating acid-peptic diseases.

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Authors
  1. Seppo Parkkila
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  2. Anna-Kaisa Parkkila
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  3. Juhani Lehtola
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  4. Alli Reinila
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  5. Hannu-Jaakko Sodervik
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  6. Matti Rannisto
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  7. Hannu Rajaniemi
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Parkkila, S., Parkkila, AK., Lehtola, J. et al. Salivary Carbonic Anhydrase Protects Gastroesophageal Mucosa from Acid Injury. Dig Dis Sci 42, 1013–1019 (1997). https://doi.org/10.1023/A:1018889120034

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  • DOI: https://doi.org/10.1023/A:1018889120034

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