Abstract
Effect of intraperitoneal injection of endothelin-1 on DNA synthesis in the myocardium of newborn albino rats was studied by 3H-thymidine autoradiography. Endothelin-1 injected in a single dose of 10 g/kg stimulated proliferative processes: the index of labeled nuclei and labeling intensity increased. Repeated (5 times) administration of endothelin-1 in doses of 1 and 10 g/kg increased labeling intensity, but did not change the index of labeled nuclei. The data suggest that endothelins are involved in morphogenesis of the myocardium during the early postnatal ontogeny.
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Sazonova, E.N., Sazonov, O.A., Lebed'ko, O.A. et al. Effect of Endothelin-1 on DNA Synthesis in the Myocardium of Albino Rats during Early Postnatal Ontogeny. Bulletin of Experimental Biology and Medicine 130, 1144–1146 (2000). https://doi.org/10.1023/A:1017563414203
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DOI: https://doi.org/10.1023/A:1017563414203